肝脏18F-FDG PET半定量方法比较分析

 目的  比较肝脏18氟脱氧葡萄糖正电子发射体层摄影/计算机体层摄影［2-(fluorine-18)-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography,18F-FDG PET/CT］半定量方法及其受血糖、血脂、肝酶、体质指数 (body mass index,BMI)、年龄及性别等因素的影响。方法  回顾性分析678例健康人群PET/CT、常见血液化验结果及基本信息等资料,测量肝脏平均标准化摄取值 (standardized uptake value,SUV)和基于瘦质体重 (lean body mass,LBM)与体表面积 (body surface area,BSA)校正的SUVLBM和SUVBSA。比较三者的变异系数大小,并采用相关、偏相关和多元线性回归分析比较三者受血液化验指标的影响程度。结果  SUV、SUVLBM和SUVBSA的变异系数 (23.3%、23.4%和24.7%)相当。SUV受年龄、BMI、高密度脂蛋白 (high density lipoprotein,HDL)和三酰甘油 (triglyceride,TG)的影响 (P值均<0.05),SUVBSA受性别、年龄、BMI和HDL的影响 (P值均<0.05),而SUVLBM仅与性别和年龄有关 (β=0.092和0.004,P=0.002和0.007),不受常见血液化验指标的影响。结论  肝脏SUV和SUVBSA均受常见血液指标的影响,而SUVLBM不受血液化验指标的影响,有望用于18F-FDG PET半定量评估。

Semi-quantitative methods for hepatic 18F-FDG PET: a comparative study

Objective  To compare semi-quantitative methods of hepatic 2-(fluorine-18) -fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and their influencesby factors,such as blood glucose,blood lipids,liver enzymes,BMI,age and gender. Methods  Data on PET/CT,common serum biochemical test results and basic information from 678 healthy people were retrospectively collected.Mean SUV of liver was measured and corrected based on lean body mass (LBM) and body surface area (BSA) of each subject,which were named as SUVLBM and SUVBSA,respectively.Coefficients of variation (CV) of SUV,SUVLBM and SUVBSA were compared to estimate their inter-individual variations. Correlation, partial correlation and multiple linear stepwise regression analysis were performed to identify the variability of these three measurements to common serum biochemical indices. Results  CV of SUV,SUVLBM and SUVBSA was comparable to each other (23.3%,23.4% and 24.7%,respectively).SUV was significantly affected by age,body mass index  (BMI),high density lipoprotein (HDL) and triglyceride (TG),with P-value all less than 0.05; SUVBSA was significantly affected by gender,age,BMI and HDL,with P-value all less than 0.05; while SUVLBM was only affected by gender and age (β=0.092,0.004;P=0.002,0.007). Conclusions  SUV and SUVBSA of liver were affected by common serum biochemical indices while SUVLBMwas not.Therefore,SUVLBM is prospective to be used for 18F-FDG PET semi-quantitative evaluation.