戒烟对冠心病患者临床指标及住院费用的影响

 目的 探讨冠脉造影术前戒烟对患者临床指标及住院费用的影响。 方法 分析2009年12月至2010年11月接受冠脉造影患者的住院资料,并按冠脉造影术前是否吸烟及戒烟分为非吸烟组127例(30.7%)、吸烟组110例(26.6%)和戒烟组177例(42.8%),比较3组患者临床指标的差异,并随访此后4年内心内科总住院天数及住院总费用。 结果 戒烟组的Gensini积分(P=0.012)和入院NT-proBNP(P=0.007)低于吸烟组;吸烟组的尿酸高于非吸烟组(P=0.001);戒烟组的non-HDL低于非吸烟组(P=0.013)和吸烟组(P=0.040)。Gensini积分、NT-proBNP、尿酸和non-HDL是病情进展和死亡率的预测因子。提示吸烟组患者存在相对较高的心血管风险,而戒烟组患者心血管危险因素有所降低。戒烟组的住院总费用低于吸烟组。 结论 戒烟可通过降低其他心血管危险因素进而减少心血管事件风险,且可降低心血管疾病负担。

Effect of smoking cessation on clinical parameters and hospitalization costs among patients with coronary artery disease

Objective  To investigate the impact of smoking cessation on clinical parameters and hospitalization costs.Methods  Patients admitted between Dec. 2009 and Nov. 2010 with coronary angiography were analyzed.According to the smoking status before coronary angiography,they were divided into non-smoking group (127 cases,30.7%),smoking group (110 cases,26.6%) and smoking-cessation group (177 cases,42.8%).Total hospitalization days and total hospitalization costs in the following four years were compared the among three groups.ResultsGensini score (P=0.012) and NT-proBNP value(P=0.007) of non-smoking group was lower than smoking group;uric acid value of smoking group was higher than non-smoking group (P=0.001);non-HDL value of smoking cessation group was lower than non-smoking group (P=0.013) and smoking group (P=0.040).Gensini score,NT-proBNP,uric acid and non-HDL are predictors of disease progression and mortality.Thus patients of smoking group have a relatively higher cardiovascular risk compared to patients of smoking cessation group. We also found hospitalization costs was higher in patients of smoking group than those of smoking cessation group.Conclusions Smoking cessation can reduce the value of other risk factors,thereby can reduce risk of cardiovascular events,and alleviate the burden of cardiovascular disease.