| “代谢记忆”与糖尿病肾病 |
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| 引用本文： | 熊晓燕(综述) 白寿军(审校). “代谢记忆”与糖尿病肾病[J]. 复旦学报(医学版), 2018, 45(2): 266. DOI: 10.3969/j.issn.1672-8467.2018.02.020 |
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| 作者姓名： | 熊晓燕(综述) 白寿军(审校) |
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| 作者单位： | 复旦大学附属中山医院青浦分院肾内科 上海 201700 |
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| 基金项目： | 上海市自然科学基金(13ZR1407200);上海市卫计委基金(20124231) |
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| 摘 要： | 高血糖“代谢记忆”现象是指糖尿病患者由于早期高血糖作用,即使后期采取有效措施将血糖控制在正常水平,仍易发生糖尿病相关的并发症。糖尿病肾病是一种常见的糖尿病微血管并发症,是患者发生终末期肾脏病的主要原因,本文主要就“代谢记忆”与糖尿病肾病发生发展的关系进行综述。
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| 关 键 词： | 代谢记忆 糖尿病肾病 表观遗传学修饰 |
| 收稿时间： | 2016-12-21 |
Metabolic memory and diabetic nephropathy |
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| XIONG Xiao-yan,BAI Shou-jun. Metabolic memory and diabetic nephropathy[J]. Fudan University Journal of Medical Sciences, 2018, 45(2): 266. DOI: 10.3969/j.issn.1672-8467.2018.02.020 |
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| Authors: | XIONG Xiao-yan BAI Shou-jun |
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| Affiliation: | Department of Nephrology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China |
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| Abstract: | Metabolic memory is a phenomenon that the diabetic complications continue to develop and progress in individuals who exposed a period of high glucose in the early stage and then returned to normal blood glucose after effective control. Diabetic nephropathy (DN) is one of the common diabetic microangiopathy and the main cause of end stage renal disease (ESRD). This review mainly summarizes the relationships between metabolic memory and the development of DN. |
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| Keywords: | metabolic memory diabetic nephropathy epigenetics |
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