疏肝健脾养心方治疗慢性乙型肝炎肝郁脾虚型的临床研究

目的]观察疏肝健脾养心方治疗慢性乙型肝患者(肝郁脾虚型)的临床疗效及安全性。方法]将72例慢性乙型肝患者(肝郁脾虚型)随机分为两组,每组36例,治疗组予疏肝健脾养心方治疗,对照组予疏肝健脾方治疗,疗程12周。观察并记录两组患者治疗前后中医证候积分、SF-36生存质量量表积分和相关生化学水平,进行临床疗效和安全性评价。结果]中医证候疗效方面,治疗组总有效率94.44%,对照组总有效率为75.00%。治疗后两组患者SF-36生存质量量表均得到改善,治疗组在生理功能、社会功能、心理健康3个维度方面疗效优于对照组(P<0.05)。两组治疗后肝功能方面均得到好转,但两组间无统计学差异(P>0.05);两组安全性指标未见明显异常。结论]疏肝健脾养心方治疗慢性乙型肝患者(肝郁脾虚型)临床疗效显著,且安全性好,值得临床推广。

Clinical observation of Shugan Jianpi Yangxin Decoction in the treatment of chronic hepatitis B patients(liver depression and spleen deficiency type)

Objective] To observe the clinical efficacy and safety of Shugan Jianpi Yangxin Decoction in the treatment of CHB patients (liver depression and spleen deficiency type). Methods] A total 72 chronic hepatitis B patients (liver depression and spleen deficiency type) were divide into two groups. Thirty six patients in the treatment group were treated with Shugan Jianpi Yangxin Decoction and 36 cases in the control group were treated with Shugan Jianpi Decoction for 12 weeks. These scores of TCM syndrome,SF-36 quality of life scale score and biochemical indexes of the two groups before and after treatment were observed and recorded,and the clinical efficacy and safety were evaluated. Results] As for the overall effect of TCM symptoms,the total effective rate of treatment group is 94.44%,and the control group is 75.00%. SF-36 quality of life scale was improved in both groups after treatment,in terms of physiological function,social function and mental health,the treatment group''s effect was better than control group (P<0.05). Liver function was improved after treatment in both groups,but no differences (all P>0.05). Both Decoctions were safe,and no toxic or side effects were found. Conclusion] Shugan Jianpi Yangxin Decoction can significantly improve the clinical efficacy of chronic hepatitis B patients (liver depression and spleen deficiency type),and it is safe for clinical use and worthy of promotion.