阻塞性睡眠呼吸暂停低通气综合征患者超敏血清C反应蛋白和T淋巴细胞亚群水平的变化及临床意义

 目的   评价阻塞性睡眠呼吸暂停低通气综合征 (obstructive sleep apnea-hypopnea syndrome,OSAHS)患者血清超敏C反应蛋白 (hypersensitive-C reactive protein,hs-CRP)和T淋巴细胞亚群 (T lymphocyte subsets,T-LS)的变化,探讨OSAHS对T-LS水平的影响及hs-CRP水平、T-LS水平与OSAHS之间的相互关系。方法   选择门诊及住院的单纯OSAHS患者59例,同期健康体检者24例作为对照组,两组之间年龄和性别等构成差异均无统计学意义。所有受试者均接受连续7 h的夜间多导睡眠仪监测以判断OSAHS患者病情的严重程度;于次日清晨采集外周静脉血5 mL,测定血清中hs-CRP和T-LS水平。结果   OSAHS组CD3+CD4+T细胞较对照组明显降低,差异有统计学意义 (P<0.05);而 CD3+、CD3+CD8+T细胞和CD4+/CD8+T细胞较对照组差异均无明显统计学意义 (P>0.05)。 结论  OSAHS患者体内存在T-LS水平的改变,可能导致不同程度的免疫功能下降。

The change and clinical significance of T lymphocyte subsets and serum hypersensitive-C reactive protein levels in patients with obstructive sleep apnea hypopnea syndrome

Objective  To evaluate the change of T lymphocyte subsets and serum hypersensitive-C reactive protein (hs-CRP) level in patients obstructive sleep apnea hypopnea syndrome (OSAHS),and to explore OSAHS′s influence on the level of T lymphocyte subsets (T-LS) and the relationship among hs-CRP,level of T lymphocyte subsets and OSAHS.Methods  A total of 59 in-patients and out-patients with OSAHS was selected as the OSAHS group,24 healthy subjects were selected as control group.There was no significant differences in gender and age between these two groups.All subjects underwent 7 hours continuous nighttime polysomnography (PSG) monitoring to access their disease severity of OSAHS.The next morning,5 mL blood was collected from peripheral vein for testing the levels of hs-CRP and T-LS.Results  Compared with control group,the level of CD3+ CD4+ T lymphocyte in OSAHS group was decreased with statistical significance,but the levels of CD3+,CD3+ CD8+ and CD4+/CD8+ T lymphocyte had no significant difference (P>0.05).
Conclusions  Changes of  T-LS level in OSAHS patients may lead to decline of immunologic function in different levels.