归芎消异方对卵巢子宫内膜异位症患者术后复发及妊娠情况的影响

 目的  观察归芎消异方对卵巢子宫内膜异位囊肿患者保守性手术后复发及妊娠情况的影响。方法  采用前瞻性非随机对照研究方法,将116例卵巢子宫内膜异位囊肿术后患者分为治疗组(51例)和对照组(65例)。治疗组采用归芎消异方口服治疗,对照组采用达菲林肌肉注射治疗,疗程为3~6个月。采用电话及门诊随访的方式随访至术后2年。比较两组患者的术后复发及妊娠情况。结果  随访过程中,治疗组和对照组的复发率分别为9.8%和10.8%,平均复发时间分别为(9.60±5.16)个月和(10.57±2.94)个月,两组的复发情况比较差异无统计学意义。治疗组和对照组中有妊娠意愿者的妊娠成功率分别为70.3%和45.7%,两组比较差异有统计学意义(P<0.05)。结论  归芎消异方可能有防止卵巢子宫内膜异位囊肿患者术后的复发、提高患者的妊娠率的作用。

Effect of Guixiong Xiaoyi Fang on recurrence and pregnancy of endometriosis patients after operation

Objective   To study the effect of Guixiong Xiaoyi Fang on recurrence and pregnancy of endometriosis patients after a conservative operation.Methods   One hundred and sixteen patients with endometriosis who received laparoscopic surgery and pathological diagnosis were chosed and analysed by a prospective nourandomized controlled study.Among them,51 cases were given  Guixiong Xiaoyi Fang orally and other 65 cases were intramuscularly injected with diphereline (GnRH-a).They were treated with the medicine for 3-6 months ,and followed up by telephone call and outpatient visit for 2 years after operation.The two groups were compared for recurrence rate and time,pregnancy rate and the indication of side reaction.Results  The recurrence rates of 2 years after operation in Guixiong Xiaoyi Fang group and GnRH-a group were 9.8% and 10.8%,respectively.There was no statistically significant difference between the two groups in recurrence rate.The pregnancy rates of 2 years after operation in Guixiong Xiaoyi Fang group and GnRH-a group were 70.3% and 45.7%,respectively.There was significant statistically difference between the two groups in pregnancy rate (P＜0.05).Conclusions  Guixiong Xiaoyi Fang may have effect on preventing recurrence and improving pregnancy in endometriosis patients after surgery.