复方苦参注射液在抗头颈部恶性肿瘤中的应用

 复方苦参注射液是一种广泛应用于临床的纯中药制剂,由苦参、白土苓等中草药提取加工而成,主要含苦参碱、氧化苦参碱等有效成分,近年来其在抗头颈部恶性肿瘤 (head and neck carcinoma,HNC)中的应用越来越受到关注。本文就复方苦参注射液与放化疗联合应用的增效减毒、增强免疫系统保护作用、缓解癌性疼痛等临床应用,及其抑制肿瘤细胞增殖、阻滞肿瘤细胞周期、促进肿瘤细胞凋亡、逆转肿瘤细胞耐药性等作用机制进行综述,探讨其在头颈部恶性肿瘤中的应用价值。

Application in anti-head and neck carcinoma of matrine compound injections

Matrine compound injections is a traditional Chinese herb which used widely in clinical medicine.It is extracted and processed from several herbs like Sophora flavescens Ait and Smlax glabra Roxb,and mainly contains matrine and oxymatrine.The application of the injections in anti-head and neck carcinoma (HNC) got more and more attention in recent years.This article summarized its synergism and attenuation action combined with the adjuvant therapy of radiotherapy and chemotherapy,its potentiation role in the protection of the immune system and cancer pain remission,as well as its regulating machenisms:inhibiting cancer cells proliferation,inducing cell cycle arrest,eliciting apoptosis,reversing the multi-drug resistance and the like,meanwhile discussed the application value of this drug.