| 母代肥胖对子代的影响及其机制的研究进展 |
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| 引用本文： | 杨天(综述) 刘晟骅 胡梦博 张立旻 姜昊文 (审校) 丁强. 母代肥胖对子代的影响及其机制的研究进展[J]. 复旦学报(医学版), 2016, 43(6): 738. DOI: 10.3969/j.issn.1672-8467.2016.06.017 |
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| 作者姓名： | 杨天(综述) 刘晟骅 胡梦博 张立旻 姜昊文 (审校) 丁强 |
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| 作者单位： | 复旦大学附属华山医院泌尿外科-复旦大学泌尿外科研究所 上海 200040 |
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| 基金项目： | 国家自然科学基金(81272835) |
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| 摘 要： | 超重和肥胖是影响现代人健康的一个重要因素。高脂高糖饮食和不健康的生活习惯是导致成人肥胖的主要原因，而近年来许多研究提示母代肥胖及相关的代谢紊乱也会影响其子代，提高子代罹患肥胖、糖尿病、哮喘，心血管等疾病的概率。本综述总结了这一过程发生的相关机制，包括一氧化碳(nitric oxide, NO)和前列腺素途径、高血糖症和胰岛素抵抗、活性氧(reactive oxygen species, ROC)的产生、脂毒性以及瘦素对下丘脑摄食中枢的调节作用。
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| 关 键 词： | 母代肥胖 子代 影响机制 |
| 收稿时间： | 2015-10-20 |
Research progress in the mechanisms of influence from maternal obesity to offspring |
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| YANG Tian,LIU Sheng-hua,HU Meng-bo,ZHANG Li-min,JIANG Hao-wen,DING Qiang. Research progress in the mechanisms of influence from maternal obesity to offspring[J]. Fudan University Journal of Medical Sciences, 2016, 43(6): 738. DOI: 10.3969/j.issn.1672-8467.2016.06.017 |
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| Authors: | YANG Tian LIU Sheng-hua HU Meng-bo ZHANG Li-min JIANG Hao-wen DING Qiang |
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| Affiliation: | Department of Urology, Huashan Hospital, Fudan University-Institue of Urology, Fudan University, Shanghai 200040, China |
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| Abstract: | Overweight and obesity are seriously impacting the whole population nowadays. Though high-fat or high-sugar diet and an unhealthy life style are the main causes of obesity in adult, recent researches suggest that maternal obesity and related metabolic disorders may affect the offspring, resulting in diseases like obesity, diabetes, asthma and cardiovascular symptoms. This review summarized some mechanisms of influence from maternal obesity to offspring including arachidonic acid-prostaglandin pathway and nitric oxide pathway, hyperglycaemia and insulin resistance, reactive oxygen species, lipotoxicity, and the effect of leptin to hypothalamus. |
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| Keywords: | maternal obesity offspring influence mechanisms |
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