| 胰腺导管腺癌局部治疗联合免疫治疗研究进展 |
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| 引用本文： | 杨敏捷,(综述),王小林,(审校). 胰腺导管腺癌局部治疗联合免疫治疗研究进展[J]. 复旦学报(医学版), 2018, 45(1): 93-100. DOI: 10.3969/j.issn.1672-8467.2018.01.015 |
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| 作者姓名： | 杨敏捷 (综述) 王小林 (审校) |
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| 作者单位： | 1复旦大学附属中山医院介入治疗科 上海 200032; 2上海市影像医学研究所 上海 200032 |
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| 基金项目： | 上海市自然科学基金(16ZR1433000) |
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| 摘 要： | 胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)是恶性程度最高的肿瘤之一。越来越多的证据表明包括立体定向放射治疗(stereotactic body radiotherapy,STRT)和射频消融在内的局部治疗可能成为不可手术切除的PDAC患者的新选择。由于PDAC的单独免疫治疗效果欠佳,近年来越来越多的研究发现局部治疗可以改变肿瘤局部及远处转移灶的免疫微环境,并增加免疫治疗敏感性。可以预期,局部治疗联合免疫治疗可能提高疗效。本文主要介绍PDAC局部治疗联合免疫治疗的机制及相关临床研究进展。
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| 关 键 词： | 胰腺导管腺癌 射频消融 电穿孔治疗 程序性死亡 |
Research progress of loco-regional therapy combined with immunotherapy for pancreatic ductal adenocarcinoma |
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| YANG Min-jie,,WANG Xiao-lin,. Research progress of loco-regional therapy combined with immunotherapy for pancreatic ductal adenocarcinoma[J]. Fudan University Journal of Medical Sciences, 2018, 45(1): 93-100. DOI: 10.3969/j.issn.1672-8467.2018.01.015 |
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| Authors: | YANG Min-jie WANG Xiao-lin |
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| Affiliation: | 1Department of Interventional Radiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China; 2Shanghai Institution of Medical Imaging,Shanghai 200032,China |
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| Abstract: | Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumor worldwide.Emerging evidence has shown that loco-regional therapy such as stereotactic body radiotherapy (SBRT) and radiofrequency ablation might be a rational choice for unresectable PDAC patients.Meanwhile,immunotherapy alone for PDAC have rarely achieved encouraging results.Accumulating data have revealed prominent tumor microenvironment change after loco-regional therapy in both target and remote lesions which might sensitize immunotherapy.It is thrilling to envisage the potential benefits of the combination therapy.We will focus on the underlining mechanism and clinical studies of the combination therapy. |
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| Keywords: | pancreatic ductal adenocarcinoma radiofrequency ablation irreversible electroporation programmed death |
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