噻吗洛尔与普萘洛尔治疗高血压病与心绞痛的疗效比较

劳累性心绞痛38例采用噻吗洛尔2.5-5mg, tid,共4wk;另12例采用普萘洛尔10-20mg, tid,共4wk。结果:前者显效率为79％,显著高于后者42％(P<0.05)。高血压病(Ⅰ,Ⅱ期)37例采用噻吗洛尔治疗,方法同上;另13例采用普萘洛尔20-40mg, tid,疗程亦4wk。结果:2组均有显著降压疗效(P<0.01),噻吗洛尔治疗后1h即获显效,普萘洛尔须24h才获显效。噻吗洛尔7％(5/75)、普萘洛尔4％(1/25)治疗后发生窦性心动过缓,前者被迫停药,后者未停药。

Timolol vs propranolol in treatment of hypertension and angina pectoris

Angina of effort was treated in 38 patients with timolol 2. 5-5mg tict for 4 wk, and in 12 patients with propranolol 10-20 mg tid for 4 wk. Results showed the response rate of timolol group was 79%, compared with 42% of the propranolol group (P<0. 05). In essential hypertension, 37 patients received timolol 2. 5-5 mg tid for 4 wk and 13 patients received propranolol 20-40 mg tid for 4 wk. Results revealed total response rates of 84% in timolol group and 69% in the propranolol group (P> 0. 05). The time of antihypertensive effect of timolol group began at 1 h, and that of propranolol group was 24 h. Among timolol group, 5/75 patients had to be withdrawn owing to sinus bradycardia (SB); 1/25 patient in the propranolol group developed SB but did not need withdrawal.