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| 物料粉体学性质与中药微丸成型性相关性研究 | |
| 引用本文： | 黄洋,贾晓斌,朱静,陈斌,陈红霞,刘齐. 物料粉体学性质与中药微丸成型性相关性研究[J]. 中国中药杂志, 2010, 35(23): 3136-3139 |
| 作者姓名： | 黄洋 贾晓斌 朱静 陈斌 陈红霞 刘齐 |
| 作者单位： | 1. 江苏省中医药研究院,中药新型给药系统重点实验室,国家中医药管理局中药释药系统重点研究室,江苏,南京,210028;江苏大学,药学院,江苏,镇江,212013 2. 江苏省中医药研究院,中药新型给药系统重点实验室,国家中医药管理局中药释药系统重点研究室,江苏,南京,210028 3. 江苏省中医药研究院,中药新型给药系统重点实验室,国家中医药管理局中药释药系统重点研究室,江苏,南京,210028;南京中医药大学,江苏,南京,210046 |
| 基金项目： | 江苏省中医药领军人才专项(2006);国家中医药管理局中医药科学技术研究专项(06-07ZQ05);江苏省中医药局中医药科技技术研究专项(LZ09061) |
| 摘 要： | 目的:探讨挤出滚圆法制备微丸的过程中物料粉体学性质对成型性的影响。方法:以当归补血汤提取物为模型药物,考察提取物粉末粒径及加入辅料润湿后所得软材的黏附性对微丸成型性的影响。结果:当归补血汤提取物粉末粒径在一定范围内越小其微丸成型性越好,软材黏附系数需要在特定的范围内才能制备成圆整度较好的微丸。结论:物料的粉体学性质影响了中药微丸的成型性。 |
| 关 键 词： | 粉体学性质 中药微丸 成型性 挤出滚圆 |
| 收稿时间： | 2010-07-07 |
Correlation of powder properties and formability of traditional Chinese medicine pellets |
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| HUANG Yang,JIA Xiaobin,ZHU Jing,CHEN Bin,CHEN Hongxia and LIU Qi. Correlation of powder properties and formability of traditional Chinese medicine pellets[J]. China Journal of Chinese Materia Medica, 2010, 35(23): 3136-3139 | |
| Authors: | HUANG Yang JIA Xiaobin ZHU Jing CHEN Bin CHEN Hongxia LIU Qi |
| Affiliation: | Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Shool of Pharmacy, Jiangsu University, Zhenjiang 212013, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210046, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Shool of Pharmacy, Jiangsu University, Zhenjiang 212013, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Shool of Pharmacy, Jiangsu University, Zhenjiang 212013, China |
| Abstract: | Objective : To investigate the correlation of powder properties and formability of traditional Chinese medicine pellets prepared by extrusion/spheronization. Method : The present effort was designed to evaluate the effects of the characters of powder on pellets formation by extrusion-spheronization, taking Danggui Buxue decoction extracts as a model drug and microcrystalline cellulose (MCC) as an ideal balling material for extrusion- spheronization. Result : The diameter of powder had correlation with the plane critical angle of pellets in a certain scope and the sticky coefficient of wet mass affected roundness of pellets. Conclusion : Properties of powder have influence on formability of traditional Chinese medicine pellets. |
| Keywords: | properties of powder pellets formability extrusion- spheronization |
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