维生素A缺乏易致老年黄斑变性的实验研究

目的：通过对老龄小鼠眼局部组织中自由基的测定，探索维生素A缺乏对老年黄斑变性的诱导机制，为临床预防和治疗老年黄斑变性提供一定理论依据。方法：将昆明小鼠随机分为对照组、维生素A缺乏组和维生素A添加组，各组分别用相应饲料喂养50d，取眼球组织测定组织中自由基的含量。结果：维生素A添加组小鼠的SOD、GSH-PX、CAT活性明显高于维生素A缺乏组和对照组（P〈0.05），同时MDA含量低于维生素A缺乏组和对照组，但无统计学意义。结论：老年黄斑变性的发生与维生素A缺乏有一定的关系。

The experimental study of the aged macular degeneration for Vitamin A deficiency

Objective:To explore induced mechanism age macular degeneration for Vitamin A deficiency through determining free radicals of the aged mice ocular tissues, and to provide a theoretical basis for the prevention and treatment of the aged macular degeneration. Methods:The mice were randomly divided into the control group,the lacked of vitamin A group and the added vitamin A group, to feed each group with corresponding animal feeds for 50 days,and to determine the content of free radicals in organization of the eyeball. Results: The SOD, GSH-PX and CAT of the added vitamin A group were obviously higher than the lacked of vitamin A group and the control group, and the content of MDA was lower than the lacked of vitamin A group and the control group(P<0.05).However,there was no significant statistical significance. Conclusion: The Aged macular degeneration have a certain relationship to vitamin A deficiency.