子宫内膜异位症患者核转录因子-κB及细胞间粘附分子-1的表达

目的 检测核转录因子(NF-κB)及细胞间粘附分子-1(ICAM-1)在子宫内膜异位症(内异症)中的表达,探讨其在内异症发病中的作用。方法 采用免疫组化SP法分别检测NF-κB及ICAM-1在35例正常子宫内膜、48例内异症患者的在位内膜及76例内异症患者的异位内膜中的表达,并对检测结果进行统计学分析。结果 ①NF-κB和ICAM-1主要表达于三组内膜的腺上皮细胞,在正常子宫内膜表达最弱,而在异位内膜的表达最强(P<0.001);②NF-κB和ICAM-1在正常子宫内膜、在位内膜及异位内膜中的表达呈正相关,相关系数分别为r=0.688、r=0.773及r=0.777(P<0.01)。结论 NF-κB和ICAM-1在内异症在位内膜和异位内膜的高表达及二者之间的正相关性提示其在内异症发生发展过程中起重要的作用。

Expressions of nuclear factor-kappaB and intercellular adhesionmolecule-1 in endometriosis

Objectives To investigate the association of nuclear factor-kappaB (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) with endometriosis. Methods Immunohistochemistry was used to examine the NF-κB and VEGF protein expres-sion in 35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis and 76 ectopic endometrium, and the results were analyzed statistically. Results The expressions of NF-κB and ICAM-1 were found mainly in the glandular epithelial cells of the three endometrium specimens, with the ectopic endometriotic tissues showing the highest and normal endometrium the lowest expressions (P<0.001). NF-κB and ICAM-1 expressions were positively correlated to normal, eutopic and ectopic endometrium (r=0.688, 0.773 and 0.777, respectively, P<0.01). Conclusion NF-κB and ICAM-1 may participate in the process of the pathogenesis in endometriosis.