Comparative evaluation of the efficacy of itraconazole with terbinafine cream versus itraconazole with sertaconazole cream in dermatophytosis: A within person pilot study |
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| Institution: | 1. Department of Dermatology, Venereology and Leprosy, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi 110001, India;2. National Reference Laboratory for Antimicrobial Resistance in Fungal Pathogens, Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi 110007, India;1. University of Banja Luka, Faculty of Medicine, Department of Pharmaceutical Technology and Cosmetology, Save Mrkalja 14, 78000 Banja Luka, Bosnia and Herzegovina;2. School of Pharmacy, University College Cork, Cork, Ireland;3. University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia;4. Tyndall National Institute, University College Cork, Cork, Ireland;5. University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 11221 Belgrade, Serbia;1. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil;2. Curso de Farmácia, Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, Brazil;3. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Department of Medical Research, 251 General Airforce Hospital, Athens, Greece;3. Department of Pathology, Ippokration Hospital, Thessaloniki, Greece;4. Department of Radiology, Ippokration Hospital, Thessaloniki, Greece;5. Department of Clinical Therapeutics, School of Medicine, University of Athens, Athens, Greece |
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| Abstract: | BackgroundCurrent trend of rising drug-resistant dermatophyte infection is alarming and fretted by dermatologists. Dilemma prevails regarding use of the same or different class of antifungal agents topically and systemically. The aim was to study the efficacy of oral itraconazole 200 mg with 1% terbinafine cream versus oral itraconazole 200 mg with 2% sertaconazole cream in dermatophytosis.MethodsThis within-person open-label pilot study enrolled 50 patients with dermatophytosis. Two lesions of comparable size within each patient were randomly allotted to group A and B and treated with 2% sertaconazole and 1% terbinafine cream, respectively. Both groups received itraconazole 200 mg once daily for 4 weeks. The remaining lesions received 1% terbinafine cream. Response and adverse effects were assessed at 2 and 4 weeks. Reduction in erythema, scaling, pruritus and clinical, and mycological cure constituted efficacy outcomes.ResultsThe mean duration of lesions was 2.82 ± 1.35 months. Complete clinical cure was observed in 50% and 48%, whereas mycological cure was attained in 56% and 52% patients in groups A and B, respectively, after 4 weeks, which was statistically insignificant. Reduction in erythema, scaling, and pruritus after 4 weeks when compared between the two groups, was also statistically insignificant.ConclusionSame class of oral and topical antifungal agents has comparable efficacy with different classes of oral and topical antifungal agents in dermatophyte infection. |
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| Keywords: | Antifungals Dermatophyte Itraconazole Sertaconazole cream Terbinafine cream |
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