Chronic Phase Intracranial Hemorrhage Caused by Ruptured Pseudoaneurysm Induced by Carmustine Wafer Implantation for Insulo-opercular Anaplastic Astrocytoma: A Case Report |
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Authors: | Kimitoshi SATO Mitsuru DAN Daisuke YAMAMOTO Yoshiteru MIYAJIMA Atsuko HARA Toshihiro KUMABE |
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Affiliation: | 1.Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa;2.Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa |
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Abstract: | Carmustine wafers improve the survival of patients with high-grade gliomas, but several adverse events have been reported. A 42-year-old man with left insulo-opercular anaplastic astrocytoma developed a massive intra-cavital hematoma with subarachnoid hemorrhage caused by ruptured pseudoaneurysm of the left middle cerebral artery (MCA) adjacent to the site of carmustine wafers implanted 6 months previously. Intraoperative finding demonstrated a dissection of the insular portion of the MCA, and pathological examination identified the resected pseudoaneurysm. This case demonstrates that carmustine wafers can cause changes in local vessels. Therefore, implantation of carmustine wafers near to important vessels passing close to the resection cavity should be considered with great caution. |
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Keywords: | biodegradable 1,3-bis(2-chloroethyl)-1-nitrosourea wafers carmustine wafers Gliadel® pseudoaneurysm intracranial hemorrhage |
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