角膜新生淋巴管与血管内皮生长因子C

角膜新生淋巴管（CL）存在于血管化角膜上，常引起并加重角膜混浊和角膜移植排斥反应，是重要的致盲原因之一。血管内皮生长因子C（VEGF—C）是血管内皮生长因子（VEGF）家族成员之一，是VEGFR-2和VEGFR-3受体的配体。VEGF-C通过与VEGFR-3结合促进淋巴管增生，是一个特异性的淋巴管生长因子，在CL形成中起着重要的作用。就近年来CL研究进展及与VEGF—C的关系进行综述。

Corneal lymphangiogenesis and vascular endothelial growth factor C

Normal cornea is devoid of blood and lymphatic vessels but can become vascularized in wide range of clinical status such as chemical burn,infection,surgical invasion.Corneal lymphangiogenesis (CL) has been reported in vascularized corneas along with blood vessels over 40 years.It usually brings forth and aggravates corneal clouding and corneal graft rejection.It is one of the causes leading to blindness.Vascular endothelial growth factor C (VEGF-C)is one of several members of the VEGF family and is a ligand of vascular endothelial growth factor receptor-2(VEGFR-2)and vascular endothelial growth factor receptor -3 (VEGFR -3).VEGF-C induces lymphangiogenesis by binding to VEGFR-3.It is shown to be a relatively specific lymphangiogenic growth factor and plays an important role in the formation of corneal lymphangiogenesis.Recent research progress in corneal lymphangiogenesis and the relationship between CL and VEGF-C is the focus of this article.