| L-肉碱对奥硝唑所致弱精子症大鼠的治疗作用 |
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| 引用本文： | 张稳,刘清珍,商学军,黄宇烽,王浩洋.L-肉碱对奥硝唑所致弱精子症大鼠的治疗作用[J].中华男科学杂志,2009,15(7):604-607. |
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| 作者姓名： | 张稳 刘清珍 商学军 黄宇烽 王浩洋 |
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| 作者单位： | 1. 南京军区南京总医院,计划生育办公室,江苏,南京,210002
2. 南京军区南京总医院,解放军检验医学研究所,江苏,南京,210002 |
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| 摘 要： | 目的:探讨L-肉碱(LC)对奥硝唑(ORN)所致的弱精子症雄性大鼠的治疗作用。方法:性成熟雄性SD大鼠(200～230g)40只,随机均分为5组,连续灌胃20d,1次/d,每次1ml。A组(对照组):0.5%的羧甲基纤维素钠(溶剂);B组:ORN400mg/(kg.d)];C组:ORN400mg/(kg.d)]+LC100mg/(kg.d)];D组:ORN800mg/(kg.d)];E组:ORN800mg/(kg.d)]+LC100mg/(kg.d)]。将各组半数大鼠末次给药24h后,麻醉处死,取附睾,进行精子活力检测,并对附睾尾精子进行计数,剩余大鼠进行交配实验。结果:①与A组相比,B组,D组附睾头和附睾尾精子活力显著降低(P<0.05);精子数目显著减少(P<0.05)。②与B组相比,C组精子活力明显升高(P<0.05),精子数目明显增多(P<0.05),与A组比较无显著差异(P>0.05)。③E组大鼠的精子活力没有显著的提高,精子数目无明显增多,并且与D组相比没有差别(P>0.05)。结论:LC治疗后能提高ORN所致弱精子症大鼠的精子活力,增加精子密度。
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| 关 键 词： | L-肉碱 奥硝唑 弱精子症 精子活力 精子密度 雄性大鼠 |
L-Carnitine Improves the Reproductive Function of Male Rats with Ornidazole-Induced Asthenospermia |
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| ZHANG Wen,LIU Qing-zhen,SHANG Xue-jun,HUANG Yu-feng,WANG Hao-yang.L-Carnitine Improves the Reproductive Function of Male Rats with Ornidazole-Induced Asthenospermia[J].National Journal of Andrology,2009,15(7):604-607. |
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| Authors: | ZHANG Wen LIU Qing-zhen SHANG Xue-jun HUANG Yu-feng WANG Hao-yang |
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| Institution: | ZHANG Wen1,LIU Qing-zhen2,SHANG Xue-jun2,HUANG Yu-feng2,WANG Hao-yang21.Department of Family Planning,2.PLA Research Institute of Clinical Laboratory Medicine,Nanjing General Hospital of Nanjing Military Region,Nanjing,Jiangsu 210002,China |
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| Abstract: | Objective:To explore the protective effect of L-carnitine(LC)on the reproductive function of male rats with asthenospermia induced by ornidazole(ORN).Methods:Forty male SD rats(200-230 g)were randomly divided into Groups A(control:0.5% carboxymethylcellulose solution),B(medium-dose ORN:400 mg/kg/d),C(medium-dose ORN + LC:ORN 400 mg/kg/d + LC 100 mg/kg/d),D(high-dose ORN:800 mg/kg/d),and E(high-dose ORN + LC:ORN 800 mg/kg/d + LC 100 mg/kg/d).All the rats were treated via gastric gavage for 20 days consecutiv... |
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| Keywords: | L-eamitine omidazole asthenospermia sperm motility sperm count male rat |
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