Lack of evidence for hepatitis B virus (HBV) infection in fulminant non-A,non-B hepatitis |
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Authors: | Tomasz Laskus MD PhD Dr Jorge Rakela MD Russel H Wiesner MD Jeffery L Steers MD David H Persing MD PhD |
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Institution: | (1) From the Mayo Clinic and Foundation, 55905 Rochester, Minnesota;(2) Department of Medicine, University of Pittsburgh, 15213 Pittsburgh, Pennsylvania |
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Abstract: | We studied eight patients who had orthotopic liver transplantation for fulminant hepatic failure in the course of acute non-A, non-B hepatitis. HBV DNA was searched for extensively in the liver tissue by PCR using several sets of primers in conventional and heminested reactions. All patients were negative for HBV DNA in liver tissue by all assays employed; furthermore, they were negative for HEV RNA, HCV RNA, and HBV DNA in serum. Although the causative role of HEV and HCV in fulminant non-A, non-B hepatitis cannot be excluded, our data do not support a causative association between this syndrome and HBV infection.This study was supported by Grant CR20 from the Mayo Clinic and Foundation. D.H.P. is supported by Public Health Service grants AI 32403, AR 41497, and AI 30548 from the National Institutes of Health. |
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Keywords: | fulminant hepatitis HBV non-A non-B hepatitis |
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