Synthesis and Pharmacological Evaluation of Azetidin-2-ones and Thiazolidin-4-ones Encompassing Benzothiazole |
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| Authors: | Gurupadayya B M Gopal M Padmashali B Manohara Y N |
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| Institution: | Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Mysore-570 015, India;1Department of Studies in Biochemistry, Kuvempu University, Shivagangothri, Tholhunase, Davanagere-577 004, India;2Sahyadri Science College, Shimoga-577 203, India;3Department of Pharmaceutical Chemistry, National College of Pharmacy, Shimoga-577 201, India |
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| Abstract: | Various 7-chloro-6-fluoro-2-arylidenylaminobenzo(1,3)thiazole (2a-h) have been synthesized by the condensation of 7-chloro-6-fluoro-2-aminobenzo(1,3)thiazole (1) with different aromatic aldehydes. The Schiff's bases on reaction with acetyl chloride, chloroacetyl chloride and phenyl acetyl chloride yielded 1-(7-chloro-6-fluorobenzothiazol-2-yl)-3,4-substituted-aryl-azetidin-2-ones (3a-x). Similarly, cyclization of Schiff's base with thioglycolic acid furnished 3-(7-chloro-6-fluoro-benzothiazol-2-yl)-2-substituted-arylthiazolidin-4-ones (4a-h). The structures of the newly synthesized compounds have been established on the basis of their spectral data and elemental analysis. Some selected compounds were evaluated for antiinflammatory, analgesic, CNS depressant and skeletal muscle relaxant activity. |
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