PTEN、P53、ER、PR与子宫内膜癌的关系

目的:研究抑癌基因PTEN、P53在子宫内膜中的表达,探讨其临床意义。方法:采用免疫组化法,对正常子宫内膜、子宫内膜增生过长、子宫内膜不典型增生各20例,子宫内膜癌50例及子宫内膜癌旁组织50例中PTEN及P53的表达进行检测。结果:PTEN在正常子宫内膜、子宫内膜增生过长、子宫内膜不典型增生、子宫内膜癌旁组织及子宫内膜癌中表达缺失率逐渐上升,表达缺失率与组织学分级、ER、PR有关,P<0.05,差异有显著性。P53蛋白表达在子宫内膜癌中阳性率达44%,P53蛋白阳性与组织学分级、临床分期有关,P<0.05,差异有显著性。结论:PTEN、P53二者皆为抑癌基因,皆参与子宫内膜癌的发生、发展,雌孕激素可能调控PTEN的表达。

The relation of PTEN, P53, ER, PR to endometrial cancer

Objective:To study the expression and its clinical significance of PTEN and P53 in the pathogensis of endometrial carcinoma.Methods:A specific and sensitive immunohistochemical assay was used to detect the expression of PTEN and P53 in paraffin-embedded sections of 20 cases of normal endometrium,endometrial hyperplasia and atypical hyperplasia of endometrial,50 the tissue near the endometrial carcinoma and endometrial carcinoma.Results:The loss expression rates of PTEN in normal proliferative endometrium,endometrial hyperplasia,atypical hyperplasia of endometrial,the tissue near the endometrial carcinoma,and endometrial carcinoma were gradually increased.In endometrial carcinoma the loss of PTEN expression was significantly related to the cell grade,ER,PR(P<0.05).The positive rates of the aberrant expressions of P53 was 44%,and the difference was significant.The positive of the aberrant expressions of P53 was significationtly related to the cell grade,the clinicial stage(P<0.05).Conclusion:PTEN and P53 may play some roles in the carcinogenesis and development of endometrial carcinoma.Estrogen-progesterone may control the expression of PTEN.