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Osteopontin,asbestos exposure and pleural plaques: a cross-sectional study
Authors:Giuseppe Mastrangelo  Gianluca Marangi  Maria N Ballarin  Silvia Michilin  Aline SC Fabricio  Flavio Valentini  John H Lange  Ugo Fedeli  Luca Cegolon  Massimo Gion
Affiliation:(1) Department of Environmental Medicine and Public Health, Padua University, Padua, Italy;(2) Occupational Health Service, Primary Care Trust 12, Venice, Italy;(3) ABO Association, Regional Centre for the Study of Biological Markers of Malignancy, Department of Clinical Pathology, Local Health Authority 12, Venice, Italy;(4) Occupational Health Service, Occupational Health Service, Primary Care Trust 13, Dolo (Venice), Italy;(5) Envirosafe Training and Consultants, P.O. Box 114022, Pittsburgh, PA 15239-0522, USA;(6) Regional Epidemiological Service, Veneto Region, Castelfranco Veneto (TV), Venice, Italy;(7) Imperial College London, School of Public Health, St. Mary’s Campus, London, UK;(8) Regional Centre for the Study of Biological Markers of Malignancy, Department of Clinical Pathology, Primary Care Trust 12 - Venice, Venice, Italy
Abstract:

Background  

Osteopontin (OPN) is a plasma protein/cytokine produced in excess in several malignancies. In a recent study OPN was reported as being related to the duration of asbestos exposure and presence of benign asbestos-related diseases; however, it was unclear whether this protein was an indicator of exposure or effect.
Keywords:
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