| RADIOIMMUNOIMAGING OF HUMAN BREAST CANCER XENOGRAFTS IN NUDE MICE BY USING HUMAN ANTI-HUMAN BREAST CANCER MONOCLONAL ANTIBODIES |
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| 作者姓名： | 孙强 王树蕙 黄汉源 杨子毅 朱预 |
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| 作者单位： | [1]DepartmentofSurgery,PekingUnionMedicalCollegeHospital,CAMS＆PUMC,Beijing100730 [2]DepartmentofMicrobiologyandImmunology,InstituteofBasicMedicalSciences,CAMS＆PUMC,Beijing100005 |
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| 摘 要： | In this study, the human breast cancer-bearing nude mice model has been eslabgshed and the radioimrnunoimaging was carried oot by using human anti-human monoclonal antibodies. The results showed that the breast tumor-bearlng nude mice received ^3]I-McAb-CM-1 had a clear image of the xenograft during 4 to 6 days aiter injection and m lhe same lime T/NT all over 1.0. The highest T/NT reached 7.1. It demonstrates that McAb-CM-1 can specially combine veirh breast cancer tissues and hopefully it could be used clinically to improve accurate rate of the early breast cancer diagnosis.
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| 关 键 词： | 乳腺癌 单克隆抗体 动物模型 试验 ^[3]I-McAb-CM-1 放射性诊断 |
RADIOIMMUNOIMAGING OF HUMAN BREAST CANCER XENOGRAFTS IN NUDE MICE BY USING HUMAN ANTI-HUMAN BREAST CANCER MONOCLONAL ANTIBODIES |
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| Q Sun,S Wang,H Huang,Z Yang,Y Zhu.RADIOIMMUNOIMAGING OF HUMAN BREAST CANCER XENOGRAFTS IN NUDE MICE BY USING HUMAN ANTI-HUMAN BREAST CANCER MONOCLONAL ANTIBODIES[J].Chinese Medical Sciences Journal,1997,12(2):80-83. |
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| Authors: | Q Sun S Wang H Huang Z Yang Y Zhu |
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| Institution: | Department of Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730. |
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| Abstract: | In this study, the human breast cancer-bearing nude mice model has been established and the radioim-munoimaging was carried out by using human anti-human monoclonal antibodies. The results showed that the breast tumor-bearing nude mice received 131I-McAb-CM-l had a clear image of the xenograft during 4 to 6 days after injection and at the same time T/NT all over 1. 0. The highest T/NT reached 7.1. It demonstrates that McAb-CM-1 can specially combine with breast cancer tissues and hopefully it could be used clinically to improve accurate rate of the early breast cancer diagnosis. |
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| Keywords: | breast cancer human anti-human antibodies radioimmunoimaging |
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