自制可回收下腔静脉滤器预防急性肺栓塞的实验研究

目的 探讨一种新型可回收下腔静脉滤器预防急性肺栓塞的有效性、安全性.方法 12只犬制备成髂股深静脉血栓模型,分为滤器组(实验组)与无滤器组(对照组),每组6只.滤器组在深静脉血栓脱落前于对侧股静脉置入下腔静脉滤器,其后使血栓脱落;对照组直接使血栓脱落即形成肺动脉栓塞.通过血栓脱落前后的肺动脉造影、肺动脉测压以及动脉血氧饱和度测定评价滤器的血栓捕获性能.结果 滤器组均成功捕获脱落的深静脉血栓,无一例发生肺动脉栓塞,8 h后滤器均能成功回收;而对照组在推注血栓后均发生了肺动脉栓塞.结论 自制可回收下腔静脉滤器能有效预防下肢深静脉急性血栓脱落引起的肺动脉栓塞,其置入和回收简便.

Experimental evaluatioin of a new retrievable inferior vena cava filter for protection from acute pulmonary embolism in canine

Objective To evaluate the validity,safety and feasibility of a new retrieval inferior vena cava filter for the prevention of pulmonary embolism in an animal model.Methods The model of deep ilio-femoral venous thrombosis was established in 12 experimental dogs.In control group(6 experimental dogs),the deep venous thrombosis was made to fall off directly.In experimental group(6 experimental dogs),the deep venous thrombosis was made to fall off with an implanted filter in inferior vena cava.The filter's thrombus-trapping efficacy was evaluated by angiography of pulmonary artery,measurement of the mean pressure of pulmonary artery and arterial oxygen saturation before and after the deep venous thrombu falling off.Results All filters implanted in the experimental dogs could successfully capture clot coming from deep venous thrombosis.There was no case of pulmonary embolism in experimental groups.On the other hand,pulmonary embolism occurred following the fall of deep venous thrombous in all dogs of control group.Conclusion The retrievable inferior vena cava filter can effectively prevent from the pulmonary embolism due to falling off of the emboli from deep venous thrombosis.The process of implantation and retrieval is relatively simple and easy.