| 明胶-阿霉素抗癌缓释剂对膀胱肿瘤细胞株BIU-87的生长抑制研究 |
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| 引用本文： | 陈杰,叶章群,周惜才,张旭,章咏裳. 明胶-阿霉素抗癌缓释剂对膀胱肿瘤细胞株BIU-87的生长抑制研究[J]. 华中科技大学学报(医学版), 1999, 28(3): 232-234 |
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| 作者姓名： | 陈杰 叶章群 周惜才 张旭 章咏裳 |
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| 作者单位： | 1. 同济医科大学附属协和医院外科,武汉,430022
2. 同济医科大学附属同济医院外科,武汉,430030 |
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| 摘 要： | 应用含２０ｍｌ／Ｌ小牛血清的完全培养基浸泡明胶－阿霉素抗癌缓释剂，每隔２４ｈ重复更换培养基，而后将每ｄ浸泡所得的培养基与ＢＩＵ－８７细胞混合培养。结果发现，直至第１９ｄ经抗癌缓释剂浸泡过的培养基仍对ＢＩＵ－８７细胞具有生长抑制作用，其中第１ｄＢＩＵ－８７细胞生长率仅为１０％，第５ｄＢＩＵ－８７细胞生长率为６０％，第１９ｄＢＩＵ－８７细胞生长率仍低于８０％。这为明胶－阿霉素抗癌缓释剂应用于临床治疗膀胱肿瘤提供了实验依据。
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| 关 键 词： | 明胶；阿霉素；膀胱肿瘤 |
Study on Growth Suppression of Gelatia-adriamycin Antineoplastic Sustained Release Drug System on the Bladder Tumor Cell Line BIU-87 |
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| Chen Jie,Ye Zhangqun,Zhou Xicai et al. Study on Growth Suppression of Gelatia-adriamycin Antineoplastic Sustained Release Drug System on the Bladder Tumor Cell Line BIU-87[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1999, 28(3): 232-234 |
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| Authors: | Chen Jie Ye Zhangqun Zhou Xicai et al |
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| Affiliation: | Chen Jie1,Ye Zhangqun2,Zhou Xicai2 et al 1Department of Urology,Tongji Hospital,Tongji Medical University,Wuhan 4300302Department of Urology,Xiehe Hospital,Tongji Medical University,Wuhan 430022 |
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| Abstract: | Gelatiaadriamycin antineoplastic sustained release drug system was impregnated into the culture medium containing 20% bovine serumThe medium was substituted every 24 h Then the human bladder tumor cell line BIU87 was coincubated with the substituted medium every day It was found that the substituted medium on 19 day still had growth suppression effects on the BIU87 cellsThe growth rate of BIU87 cells at first, 5th and 19th day was only 10 %, 60 % and less than 80 %, respectively. Therefore, the results provided experimental evidences for the possibility that gelatiaadriamycin antineoplastic sustained release drug system could be used in the therapy for bladder tumors |
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| Keywords: | gelatia adriamycin bladder tumors |
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