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In vivo proton magnetic resonance spectroscopy assessment for muscle metabolism in neuromuscular diseases |
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| Authors: | Hsieh Tsyh-Jyi Wang Chien-Kuo Chuang Hung-Yi Jong Yuh-Jyh Li Chun-Wei Liu Gin-Chung |
| Affiliation: | a From the Department of Medical Imaging, Kaohsiung Medical University Hospital, Taiwan b Department of Clinical Research, Kaohsiung Medical University Hospital, Taiwan c Department of Pediatrics, Kaohsiung Medical University Hospital, Taiwan d Department of Radiology, Kaohsiung Municipal Hsiao-Kang Hospital, Taiwan e Department of Radiology, Faculty of Medicine, College of Medicine, Taiwan f Department of Pediatrics, Faculty of Medicine, College of Medicine, Taiwan g Faculties of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan h Medical Radiation Technology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. |
| Abstract: | Muscle metabolites were obtained by in vivo proton magnetic resonance spectroscopy of 3 patients with Duchenne muscular dystrophy (DMD), 6 patients with spinal muscular atrophy (SMA), and 10 normal volunteers. Patients with DMD and SMA had lower trimethyl amide (TMA)/water and TMA/total creatine (tCr) ratios but normal tCr/water ratios. |
| Keywords: | DMD, Duchenne muscular dystrophy MRI, Magnetic resonance imaging MRS, Magnetic resonance spectroscopy SMA, Spinal muscular atrophy TCr, Total creatine TMA, Trimethyl amide |
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