| T细胞酶联免疫斑点法对艾滋病合并结核病患者的诊断价值研究 |
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| 引用本文： | 欧阳晖,陈柏林.T细胞酶联免疫斑点法对艾滋病合并结核病患者的诊断价值研究[J].实用预防医学,2010,17(10):1950-1953. |
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| 作者姓名： | 欧阳晖 陈柏林 |
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| 作者单位： | 湖南省结核病防治所,湖南,长沙,410013 |
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| 摘 要： | 目的探讨T细胞酶联免疫斑点法(T.SPOT-TB)在艾滋病合并结核病患者中的诊断价值。方法应用T.SPOT-TB对57例诊断明确的艾滋病合并结核病患者的血液样本进行检测并分析不同因素对T.SPOT-TB诊断价值的影响,同时对所有患者做结核菌素皮试(TST)试验进行比较。结果在艾滋病合并结核病的所有患者、肺结核组、肺外结核组、肺结核初治组、肺结核复治组的各组患者中,T.SPOT-TB的阳性检出率分别为80.70%、77.41%、88.46%、72.73%、80.00%;而TST试验的阳性检出率分别为22.81%、25.81%、19.23%、54.54%、10.00%。在患者总体、肺结核组、肺外结核组、复治组中,T.SPOT-TB检测的阳性检出率均高于TST试验(P0.05)。结论对于MTB/HIV双重感染患者,T.SPOT-TB检测的敏感性高于目前常用的TST试验,且不受结核发病部位和初复治类型的影响,适用于我国艾滋病合并结核病的快速诊断。
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| 关 键 词： | 获得性免疫缺陷综合征 结核 T细胞酶联免疫斑点法 结核菌素皮试 诊断 |
Diagnostic Value of T Cell Enzyme-Linked Immunospot Assay in Patients with AIDS Complicated by Tuberculosis |
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| OU Yang-hui,CHEN Bo-lin.Diagnostic Value of T Cell Enzyme-Linked Immunospot Assay in Patients with AIDS Complicated by Tuberculosis[J].Practical Preventive Medicine,2010,17(10):1950-1953. |
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| Authors: | OU Yang-hui CHEN Bo-lin |
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| Institution: | OU Yang-hui,CHEN Bo-lin(Hunan Provincial Institute for Tuberculosis Prevention and Treatment,Changsha 410013,Hunan,China) |
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| Abstract: | Objective To evaluate the diagnostic value of T cell enzyme-linked immunospot(T.SPOT-TB) assay in patients with acquired immunodeficiency syndrome (AIDS) complicated by tuberculosis.Methods The T.SPOT-TB assay was employed to detect ESAT-6 and CFP-10 specific T cells in blood samples from 57 AIDS patients with Mycobacterium tuberculosis(MTB) infection,and the influence by different factors to the diagnostic value of T.SPOT-TB assay was analyzed.The results were compared with those of tuberculin skin test(TS... |
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| Keywords: | Acquired immunodeficiency syndrome Tuberculosis T cell enzyme-linked immunospot assay Tuberculin skin test Diagnosis |
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