| 超微粉碎技术提高损伤胶囊溶出度的研究 |
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| 引用本文： | 姜华,詹文强. 超微粉碎技术提高损伤胶囊溶出度的研究[J]. 中药新药与临床药理, 2004, 15(5): 358-360 |
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| 作者姓名： | 姜华 詹文强 |
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| 作者单位： | 甘肃省中医药研究院,兰州,730020 |
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| 摘 要： | 目的研究超微粉碎技术对损伤胶囊溶出度的影响.方法以有效成分的溶出量及三七皂苷 R1为指标,对不同粉碎技术制备的损伤胶囊和损伤散进行溶出度和含量测定比较.结果 损伤胶囊(超微细粉)较损伤散(普通细粉)在薄层色谱图上的斑点大且显色深,限时溶出量提高 4.66 %,三七皂苷R1的含量提高 6 %.结论 超微粉碎技术能提高损伤胶囊的溶出度,为确立损伤胶囊的制备工艺提供了依据.
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| 关 键 词： | 损伤胶囊 超微粉碎 溶出度 三七皂苷R1 HPLC法 |
| 文章编号： | 1003-9783(2004)05-0358-03 |
| 修稿时间： | 2004-04-12 |
Studies on Super Fine Crushing Technique in Increasing Dissolution Rate of Sunshang Capsule |
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| JIANG Hua,ZHAN Huaqiang. Studies on Super Fine Crushing Technique in Increasing Dissolution Rate of Sunshang Capsule[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2004, 15(5): 358-360 |
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| Authors: | JIANG Hua ZHAN Huaqiang |
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| Abstract: | Objective To investigate the influence of super fine crushing technique on dissolution rate of Sunshang Capsule (SC). Methods With the dissolution of active components and notoginsengside as the markers, the dissolution rate in Sunshang Capsule and Sunshang powder which were prepared by super fine crushing method and fine crushing method respectively was compared by TLC and HPLC. Results The stain of Sunshang Capsule was bigger and darker than that of Sunshang Powder, time-limited dissolution of SC was 4.66 %higher and the content of notoginsengside R1 was 6 %higher than those of Sunshang Powder. Conclusion Super fine crushing technique can increase the dissolution rate of SC and this will supply evidence for the process of SC preparation. |
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| Keywords: | Sunshang Capsule Super fine crushing Dissolution rate Notoginsengside R1 HPLC |
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