灼口综合征患者情绪障碍与血清白介素-2和白介素-6浓度的关系

目的　探讨灼口综合征(BMS)患者血清IL-2和IL-6浓度与情绪障碍间的相关性。方法　采用酶联免疫吸附测定法(ELISA)检测48例BMS患者血清IL-2、IL-6的浓度,并采用汉密顿抑郁量表评定患者的抑郁症状。结果　伴有或不伴有抑郁的BMS患者血清IL-2、IL-6浓度无显著差异,但汉密顿抑郁量表与疼痛程度呈正相关。结论　本研究支持BMS患者与情绪障碍有关,汉密顿抑郁量表可用作临床评定BMS患者的抑郁状态,并为临床治疗提供参考;BMS患者血清IL-2、IL-6的浓度与患者抑郁症状无相关性。

Correlations among Mood Disorder, Serum Interleukin-2 and Interleukin-6 in Patients with Burning Mouth Syndrome

Objective To examine serum IL_2 and IL_6 levels in BMS patients with or without depression and make clear the relationship between serum IL_2, IL_6 and mood disorder.Methods Serum IL_2 and IL_6 were examined in 48 BMS patients by means of ELISA. The Hamilton Depression Rating Scale (HDRS) was used to evaluate the depressive symptomatology.Results There was no significant difference in serum IL_2 and IL_6 among BMS patients with or without depression. Mood disorder was not correlated to serum IL_2 and IL_6, but positively correlated to pain levels.Conclusion Depression status may not influence serum IL_2 and IL_6 levels significantly, but it has a relationship with BMS. The HDRS can be used to determine depression status in BMS patients in order to help clinical treatment.