Radiofrequency renal ablation: in vivo comparison of internally cooled, multitined expandable and internally cooled perfusion electrodes

PURPOSE: To evaluate the in vivo efficiency of radiofrequency ablation using an internally cooled-perfusion (ICP) electrode for inducing coagulation necrosis compared with those of RFA using internally cooled or multitined expandable electrodes in porcine kidneys. MATERIALS AND METHODS: Using a 200 W generator and internally cooled and ICP electrodes or a 150 W generator and a multitined expandable electrode, a total of 15 radiofrequency ablations were performed in the kidneys of nine pigs. After placement of an electrode in the lower pole of a kidney, one ablation zone was created using one of three different regimens: group A, radiofrequency ablation using an internally cooled electrode; group B, radiofrequency ablation using an ICP electrode with 14.6% NaCl solution instillation at 1 mL/minute; group C, radiofrequency ablation using a multitined expandable electrode. Three days after the procedures, contrast-enhanced CT scans were obtained to evaluate ablation region volumes, and kidneys were harvested for gross measurements. The three groups were compared with respect to technical parameters such as changes in impedance and current during radiofrequency ablation. The dimensions of thermal ablation zones created in the three groups were compared histologically. RESULTS: In vivo study showed that ICP electrode allowed a greater energy delivery than internally cooled or multitined expandable electrode during radiofrequency ablation: 63.3 +/- 8.8 kJ in group A; 101 +/- 3.3 kJ in group B; and 61.8 +/- 12.5 kJ (P < .05). In vivo studies showed radiofrequency ablation using ICP electrode achieved larger mean coagulation volumes than radiofrequency ablation using the other electrodes: 12.0 +/- 3.9 cm(3) in group A; 30.5 +/- 7.6 cm(3) in group B; and 11.6 +/- 6.7 cm(3) in group C (P < .05). In addition, group B had a larger mean short-axis diameter of radiofrequency-induced coagulation necrosis than groups A or C: 2.6 +/- 0.5 cm in group A; 3.6 +/- 0.4 cm in group B; and 2.4 +/- 0.7 cm in group C (difference between groups B and C: P < .05). CONCLUSIONS: Radiofrequency ablation using an ICP electrode showed better performance at creating coagulation necrosis than radiofrequency ablation using internally cooled or multitined expandable electrodes in this porcine renal model.