动脉粥样硬化不稳定斑块的研究现状

随不稳定斑块发展而继发的血栓形成是导致急性冠状动脉综合征的重要原因。在内外因素的共同作用下,不稳定斑块可能发生破裂、糜烂以及钙化等现象。斑块中存在许多直接和间接的致血栓形成的物质,它们同血液一起促进了血栓的产生。人们已经建立多种自发或诱发的不稳定斑块的动物模型。针对各种不同的影响斑块稳定性的因素,人们正从不同角度寻找能有效的稳定斑块的治疗方法。

Current status in research of vulnerable atherosclerotic plaque

The formation of thrombus as the progression of vulnerable plaque is an important cause of acute coronary syndromes.Under the influence of intrinsic and extrinsic mediators,vulnerable plaque may develop to rupture,erosion or calcification.Directly and indirectly thrombogenic components in plaque,together with blood ,contribute to the thrombus formation.Spontaneous and induced animal models have been build to help us understand plaque vulnerability.Accoring to different factors which influence plaque vulnerability,people are now exploring more effective and individualized strategies to stabilize plaque.