急性脑梗死患者血浆同型半胱氨酸水平及其相关因素分析

目的探讨急性脑梗死患者血浆同型半胱氨酸(Hcy)水平特点及其相关因素。方法高效液相色谱检测108例急性脑梗死患者和30例对照者血浆Hcy水平,对急性脑梗死患者Hcy的相关因素进行统计学分析,部分患者2周后复查血浆Hcy水平,并与入院时比较。结果急性脑梗死组患者血浆Hcy水平与对照组间差异有显著性意义(P<0.01)。性别、叶酸水平在血浆Hcy的回归方程中的标准化回归系数分别为-0.278、-0.239。病例组患者2周后血浆Hcy水平与入院时比较差异无显著性意义(P>0.05)。结论血浆Hcy水平增高可能是脑梗死的危险因素,性别、叶酸水平是急性脑梗死患者血浆Hcy水平的影响因素。

Analysis the Plasma Homocysteine Level and the Related Factors of Patients with Acute Cerebral Infarction

Objective To investigate the feature of plasma Homocysteine(Hcy) level of patients with acute cerebral infarction and the related factors.Methods The high performance liquid chromatography (HPLC) was used to detect the level of plasma Hcy in 108 patients with acute cerebral infarction and 30 control subjects who were recruited randomly.The level of plasma Hcy was re-examined two weeks later in 30 patients,and was compared with that on admission.Results The mean plasma level of Hcy in patient group was significantly higher than that of the control group( P <0.001).The standardized regression coefficients in regression equation of Hcy for gender and folic acid level were-0.278 and-0.239 respectively.There was no significant difference in the level of plasma Hcy between on admission and two weeks later( P >0.05).Conclusion The increase of plasma Hcy level might be one of risk factors of cerebral infarction; and the gender and level of folic acid were the factors influencing plasma Hcy level.