| 大鼠脑缺血再灌注后FADD、FAP—1的表达 |
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| 引用本文： | 李云峰,薛慎伍.大鼠脑缺血再灌注后FADD、FAP—1的表达[J].山西医科大学学报,2001,32(5):391-392. |
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| 作者姓名： | 李云峰 薛慎伍 |
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| 作者单位： | 济南军区总医院神经内二科, |
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| 摘 要： | 目的 探讨脑缺血再灌注后FADD、FAP－1表达的时间及表达部位。方法 用线栓法制作大鼠大脑中动脉缺血再灌注模型，用免疫组化法检测FADD、FAP－1的表达。结果 脑缺血前无FADD、FAP－1的表达，缺血再灌注后即有阳性染色，缺血再灌注12h表达最多，缺血再灌注24h阳性表达最少。海马区与皮层FADD、FAP－1的表达明显多于纹状体区。结论 大鼠脑缺血再灌注引起了FADD、FAP－1的表达，FADD、FAP－1的表达可能与凋亡有关。
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| 关 键 词： | 脑缺血 再灌注 Fas相关蛋白 Fas相关磷酸酶 大鼠 FADD FAP－1 |
| 文章编号： | 1007-6611(2001)05-0391-02 |
FADD and FAP-1 expression in rats with cerebral ischem ia/reperfusion |
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| LI Yun feng,XUE Shen wu.FADD and FAP-1 expression in rats with cerebral ischem ia/reperfusion[J].Journal of Shanxi Medical University,2001,32(5):391-392. |
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| Authors: | LI Yun feng XUE Shen wu |
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| Abstract: | Objective To study the expression of FADD and FAP 1 after cerebral ischemia/reperfusion. Methods Rat cerebral ischemia/reperfusion model was established with suture method.The expression of FADD and FAP 1 was observed with immunohistochemistry. Results Expression of FADD and FAP 1 was not found before cerebral ischemia/reperfusion,but increased significantly( P <0 01) after cerebral ischemia/reperfusion. The expression arrived at highest point at ischemia/reperfusion 12 hours.The expression of FADD and FAP 1 in hippocampus and cortex was observed more than in corpus striatum. Conclusion Rat cerebral ischemia/reperfusion induces the expression of FADD and FAP 1,and their expression may influence neuronal apoptosis. |
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| Keywords: | cerebral ischemia/reperfusion FADD FAP 1 rats Wistar |
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