Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions |
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Authors: | Nizar Al-Zoubi Hatim S AlKhatib Yasser Bustanji Khaled Aiedeh Stavros Malamataris |
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Institution: | Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, Jordan. nizoubi@yahoo.com |
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Abstract: | Sustained-release of buspirone HCl (BUH) was attempted by spray drying after dissolving in two commercially available aqueous polymeric dispersions (Eudragit RS 30 D or Kollicoat SR 30 D) at five different drug:polymer ratios (1:1, 1:2, 1:3, 1:6 and 1:9). The produced spray-dried agglomerates were evaluated in terms of their particle size and morphology, production yield, encapsulation efficiency and in-vitro release of BUH. Possible drug-polymer interactions were checked by Differential Scanning Calorimetry (DSC) and FT-IR spectroscopy. Scanning electron microscopy (SEM) was employed for the qualitative characterization of particle size and morphology. Encapsulation efficiency was generally high (around 100%) and independent of the polymeric dispersion type, while production yield was generally low (7.2-31.0%) and significantly lower for the case of Kollicoat SR 30 D (KSR) than for Eudragit RS 30 D (ERS). Scanning electron micrographs showed remarkable changes in size and shape of agglomerates due to the type of aqueous polymeric dispersion and drug:polymer ratio. In-vitro release of BUH from compacted co spray-dried agglomerates was remarkably slower and incomplete for the case of Kollicoat at drug:polymer ratio below 1, presumably due to increased plastic deformation of the developed coating instead of fragmentation in the case of Eudragit coating during compaction. |
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Keywords: | Aqueous polymeric dispersions Buspirone HCl Sustained release Spray drying Eudragit® RS 30 D Kollicoat® SR 30 D |
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