硝苯地平长效与短效制剂对高血压患者生活质量的作用比较

目的：探讨二氢吡啶类钙通道阻滞剂硝苯地平的长效制剂拜新同（nifedipine GITS，硝苯地平控释片）与短效制剂心痛定（nifedipine，硝苯地平）对轻中度高血压患者治疗作用与生活质量的影响。方法：两周停药“冲洗期”后，120例轻中度高血压病人（舒张压95-140mmHg）被随机分配到拜新同组（口服30mg，每日1次）或心痛定组（口服10mg,每日3次），疗程共3个月，治疗前后分别记录血压和填写生活质量量表。评价治疗前后治疗3个朋后生活质量的改变。结果：降压疗效两组没有显著差别，血压下降拜新同组为15/13mmHg,心痛定组为16/12mmHg(P＞0.05)；两组不良反应也无显著差别；拜新同组生活质量三个分量表得分均有明显改善，心痛定组躯体功能与心理健康得到改善，社会功能分量表质量下降，但无显著差别。结论：拜新同与心痛定降压治疗安全、有效，可改善患者的生活质量，两者比较拜新同优于心痛定，为一种比较理想的降压药物。

The Effects of Nifedipine GITS and Nifedipine on the Quality of Life in Hypertensive Patients during Antihypertensive Therapy

Objective: This study aimed to explore the effects of nifedipine GITS and nifedipine on the quality of life during antihypertensive therapy among patients with mild to moderate hypertension. Methods: A randomized clinical trial was conducted and 120 patients with mild to moderate hypertension were received nifedipine GITS (30mg/day, qd) or nifedipine (10mg/day ,tid) for 3 months follow up. Quality of life data were assessed at the beginning and end of active therapy with questionnaire. Results: 1.There were no significant differences between the two groups in the blood pressure changes(nifedipine GITS -15/13mmHg,nifedipine -16/12 mmHg). 2. There were no significant difference between the two groups in adverse events. 3. The nifedipine GITS group improved quality of life in all. 4. Nifedipine groups showed a slight improvement in quality of life.Conclusion: Both nifedipine GITS and nifedipine are safe and effective for antihypertensive therapy but the former is better than the latter as a kind of proper antihypertensive drug.