Antiretroviral blood levels in HIV/HCV‐coinfected patients with cirrhosis after liver transplant: a report of three cases |
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| Authors: | E Righi A Londero F Pea S Bonora P Nasta P Della Siega P Delle Foglie G Villa O Giglio S Dal Zoppo U Baccarani M Bassetti |
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| Institution: | 1. Infectious Diseases Department, Santa Maria della Misericordia University Hospital, Udine, Italy;2. Clinical Pharmacology Department, Santa Maria della Misericordia University Hospital, Udine, Italy;3. Infectious Diseases Department, Amedeo di Savoia Hospital, Turin, Italy;4. University Division of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy;5. Infectious Diseases Department, Trento Hospital, Trento, Italy;6. Infectious Diseases Department, Sant'Anna Hospital, Como, Italy;7. Liver Transplant Unit, Santa Maria della Misericordia University Hospital, Udine, Italy |
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| Abstract: | Since the introduction of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection is no longer a contraindication for solid organ transplantation. In HIV/hepatitis C virus (HCV)‐coinfected patients undergoing liver transplantation, HCV‐related cirrhosis, drug‐drug interactions, and calcineurin inhibitors‐related toxicity affect clinical outcomes. Therapeutic drug monitoring can be useful to assess antiretroviral over‐ or underexposure in this cohort. We report the clinical characteristics along with antiretroviral trough levels of maraviroc, darunavir, and etravirine in 3 HIV/HCV‐coinfected liver transplant recipients who developed post‐transplant liver cirrhosis. |
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| Keywords: | HIV/HCV coinfection liver transplant c‐ART cirrhosis antiretrovirals therapaeutic drug monitoring |
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