| 东莞市T2DM患者与健康人ACE基因多态性研究 |
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| 引用本文： | 刘玉华,郑小文,黄娇平,赖小惠.东莞市T2DM患者与健康人ACE基因多态性研究[J].临床心身疾病杂志,2006,12(5):324-325. |
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| 作者姓名： | 刘玉华 郑小文 黄娇平 赖小惠 |
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| 作者单位： | 523018,广东·东莞,东莞市人民医院综合科 |
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| 摘 要： | 目的研究血管紧张素转换酶基因插入（I）／缺失（D）多态性在东莞市T2DM患者与健康人中的分布。方法采用限制性片段长度多形态多聚酶链式反应（PCR—RFLP）技术对东莞市200例T2DM患者和93例健康者进行ACE基因内含子16插入／缺失（I／D）多态性检测。结果东莞市T2DM患者ACEDD、Ⅱ、ID基因型分布频率分别为8．5％、46．0％和45，5％．等位基因频率分别为I：68，8％、D：31．2％。健康对照组的频率分别为19．4％、35．5％和45，2％．等位基因频率分别为1：58，1％、D：41．9％。T2DM患者与健康对照组比较，I等位基因频率显著增高，而D等位基因频率显著降低（P％0，05）。结论ACE基因多态性是致T2DM的遗传危险因素之一。
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| 关 键 词： | 血管紧张素-I转换酶 基因多态性 2型糖尿病 |
| 文章编号： | 1672-187X（2006）05-0324-02 |
| 收稿时间： | 2006-07-25 |
| 修稿时间： | 2006年7月25日 |
Distribution of polymorphisms of angiotensin Ⅰ -converting enzyme in healthy and type 2 diabetes mellitus in Dongguan |
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| Liu Yuhua , Zheng Xiaowen, Huang Jiaoping ,et al.Distribution of polymorphisms of angiotensin Ⅰ -converting enzyme in healthy and type 2 diabetes mellitus in Dongguan[J].Journal of Clinical Psychosomatic Diseases,2006,12(5):324-325. |
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| Authors: | Liu Yuhua Zheng Xiaowen Huang Jiaoping |
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| Abstract: | Objective To investigate the distribution of polymorphisms of angiotensin 1-converting enzyme (ACE)in healthy controls and type 2 diabetes mellitus(T2DM) in Dongguan city. Methods The polymorphisms of ACE (I/D) gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 200 T2DM patients and 93 controls in Han's population of Dongguan city. Results The frequency of I allele of ACE gene polymorphisms was higher in T2DM than that in healthy controls(P<0.05), frequency of D allele was lower in T2DM than that in healthy controls(P<0.05). Conclusions Our results suggests that the ACE I/D gene polymorphism is one of inhered risk factors for T2DM development. |
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