酒精性肝炎的诊断与治疗策略

酒精性肝炎(alcoholic hepatitis,AH)尤其是重症酒精性肝炎(severe alcoholic hepatitis,SAH)一直是肝衰竭常见的、威胁生命的原因之一.患者常有长期大量饮酒史,肝损伤通常为亚急性,经过数周或数月才出现明显的临床表现.基本的治疗包括戒酒、营养支持和抗炎保肝.SAH的糖皮质激素...

Diagnosis and treatment strategies for alcoholic hepatitis

Alcoholic hepatitis (AH),especially severe alcoholic hepatitis (SAH),has been one of the most common causes of liver failure that poses a threat to human life.Patients often have a long history of heavy alcohol use.Liver injury usually presents a sub-acute course and develops significant clinical manifestations after several weeks or months.Basic treatments of AH include ab-staining from alcohol,nutrition support and anti-inflammatory and liver-protecting drugs.The use of corticosteroids(CS) in SAH is still in controversy,focusing on its risks and benefits.How to evaluate the degree of the disease,choose indications and give individual-ized treatment are important.In view of the risks of CS therapy,more attention has been paid to pentoxifylline,which has been a first-line drug for SAH.Baclofen can reduce the thirst for alcohol and has become one of the important measures in later manage-ment of AH.