| 参附注射液预处理对新生大鼠缺氧缺血后脑保护作用 |
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| 引用本文： | 杨丽娟,王军. 参附注射液预处理对新生大鼠缺氧缺血后脑保护作用[J]. 重庆医科大学学报, 2011, 36(8): 943-946 |
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| 作者姓名： | 杨丽娟 王军 |
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| 作者单位： | 1. 南京医科大学附属医院江苏淮安市第一人民医院新生儿科,南京,100202
2. 徐州医学院附属医院新生儿科,徐州221000) |
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| 摘 要： | 目的:研究参附注射液(Shenfu injection,SF)预处理对新生大鼠脑保护作用.方法:建立新生大鼠缺氧缺血性脑病(Hypoxic-ischemic encephalopathy,HIE)模型,并随机分为3组:假手术组(S),生理盐水对照组(C),参附预处理组(SF).把实验分成2部分:①检测新生大鼠缺氧缺血后...
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| 关 键 词： | 参附注射液 缺氧缺性脑病 凋亡 Bcl-2 Bax 热休克蛋白 |
Effects of Shenfu injection pretreatment on neonatal rats with hypoxicischemic encephalopathy |
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| YANG Li-Juan,WANG Jun. Effects of Shenfu injection pretreatment on neonatal rats with hypoxicischemic encephalopathy[J]. Journal of Chongqing Medical University, 2011, 36(8): 943-946 |
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| Authors: | YANG Li-Juan WANG Jun |
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| Affiliation: | YANG Li-Juan1,WANG Jun 2(1.Department of Neonatal,Huai'an First Hospital Affiliated to Nanjing Medical University,2.Department of Neonatal,the Affliated Hospital of Xuzhou Medical College) |
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| Abstract: | Objective:To study the protective effect of Shenfu injection pretreatment on neonatal rats with hypoxic-ischemic encephalopathy(HIE).Methods:HIE model rats were randomly divided into three groups:sham operation group(S),saline control group(C),and Shenfu injection pretreatment group(SF).The experiment included two parts:one was to detect the heat shock protein HSP70 and HSP90 expression 24 h after hypoxia-ischemia(HI);the second was to measure the expression of Bcl-2 and Bax of neurons in left hippocampal C... |
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| Keywords: | shenfu injection hypoxic-ischemic encephalopathy apoptosis Bcl-2 Bax heat shock protein |
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