BCG-modulated mammary carcinogenesis is dependent on the schedule of immunization but is not affected by dietary fat |
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| Affiliation: | 1. Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, NY 14263 U.S.A.;2. Breast Cancer Research Unit, Roswell Park Memorial Institute, Buffalo, NY 14263 U.S.A.;1. Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea;2. Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea;3. Department of Microbiology, Graduate School of Medicine, Ewha Womans University, Seoul, Republic of Korea;4. Department of Systems Biology and Division of Life Sciences, Yonsei University, Seoul, Republic of Korea;5. Biosystems and Bioengineering Program, Korea University of Science and Technology, Daejeon, Republic of Korea;6. Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea;7. Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea;8. Center for Plant Aging Research, Institute for Basic Science, Daegu, Republic of Korea;9. Research Institute, MD Healthcare, Seoul, Republic of Korea;10. World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan;1. Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695 019, Kerala, India;2. Agro-Processing and Technology Division, CSIR-NIIST, Thiruvananthapuram 695 019, Kerala, India;3. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India;1. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India;1. Department of Internal Medicine III, University Hospital, RWTH Aachen, Germany;2. Department of Pediatrics, University Hospital, RWTH Aachen, Germany;3. Institute of Molecular Cardiovascular Research (IMCAR), University Hospital, RWTH Aachen, Germany;4. Institute of Medical Microbiology, University Hospital, RWTH Aachen, Germany;1. Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, Hubei 430060, PR China;2. Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, Hubei 430060, PR China;1. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India |
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| Abstract: | The present study was designed to study the effect of dietary fat intake on the modulation of dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in rats injected with the methanol extract residue of Bacillus Calmette-Guerin (MER-BCG). Rats were maintained on either a 5% or a 20% corn oil diet for the entire duration of the experiment. When MER-BCG was administered 2 and 3 weeks before DMBA, mammary tumorigenesis was suppressed in the 2 dietary groups with different levels of fat intake. This was in contrast to when MER-BCG was administered 3 and 5 weeks after DMBA; in this case the development of mammary tumors was noticeably enhanced regardless of the fat intake of the host. The magnitude of inhibition or increase by MER-BCG was similar in animals fed either fat level, although a high fat diet consistently stimulated mammary tumorigenesis in the 2 experiments. In vitro assays on T cell mitogen-induced blastogenesis and natural killer cell activity in splenocytes isolated from the untreated rats showed that dietary fat failed to elicit any differential response in these immune functions. |
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