Anti-SARS CoV-2 IgG in COVID-19 Patients with Hematological Diseases: A Single-center,Retrospective Study in Japan |
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| Authors: | Takayuki Fujii Masao Hagihara Keiko Mitamura Shiori Nakashima Shin Ohara Tomoyuki Uchida Morihiro Inoue Moe Okuda Atsuhiro Yasuhara Jurika Murakami Calvin Duong Kiyoko Iwatsuki-Horimoto Seiya Yamayoshi Yoshihiro Kawaoka |
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| Affiliation: | 1.Department of Hematology, Eiju General Hospital, Japan; 2.Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan; 3.Division of Infection Control, Eiju General Hospital, Japan; 4.Division of Virology, Institute of Medical Science, University of Tokyo, Japan; 5.The Research Center for Global Viral Diseases, Research Institute, National Center for Global Health and Medicine, Japan |
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| Abstract: | Objective Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally. Although the relationship between anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies and COVID-19 severity has been reported, information is lacking regarding the seropositivity of patients with particular types of diseases, including hematological diseases. Methods In this single-center, retrospective study, we compared SARS-CoV-2 IgG positivity between patients with hematological diseases and those with non-hematological diseases. Results In total, 77 adult COVID-19 patients were enrolled. Of these, 30 had hematological disorders, and 47 had non-hematological disorders. The IgG antibody against the receptor-binding domain of the spike protein was detected less frequently in patients with hematological diseases (60.0%) than in those with non-hematological diseases (91.5%; p=0.029). Rituximab use was significantly associated with seronegativity (p=0.010). Conclusion Patients with hematological diseases are less likely to develop anti-SARS-CoV-2 antibodies than those with non-hematological diseases, which may explain the poor outcomes of COVID-19 patients in this high-risk group. |
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| Keywords: | COVID-19 SARS-CoV-2 SARS-CoV-2 IgG antibodies |
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