| Na~+/H~+交换泵1激活与心肌肥大 |
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| 引用本文： | 陈长勋,金若敏,沈云辉.Na~+/H~+交换泵1激活与心肌肥大[J].中国药理学通报,2004,20(2):121-124. |
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| 作者姓名： | 陈长勋 金若敏 沈云辉 |
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| 作者单位： | 上海中医药大学药理学教研室,上海,201203 |
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| 摘 要： | 钠氢交换泵 1介导缺血及再灌流引起的心肌损伤。近期的研究提示钠氢交换泵 1也介导长期不良刺激引起的心肌肥大和心衰。钠氢交换泵 1可能是引起心肌肥大的多种因素信息传导下游区的共同媒介 ,比如血管紧张素Ⅱ ,肾上腺α1、β1受体兴奋等。抑制钠氢交换泵 1可能会成为防治心衰的一种新方法。
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| 关 键 词： | 钠氢交换泵1 心肌肥大 血管紧张素Ⅱ 肾上腺α1受体 肾上腺β1受体 |
| 文章编号： | 1001-1978(2004)02-0121-04 |
| 修稿时间： | 2003年7月21日 |
Activation of Na+/H+ exchange 1 and myocardial hypertrophy |
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| CHEN Chang-Xun,JIN Ruo-Min,SHEN Yun-Hui-.Activation of Na+/H+ exchange 1 and myocardial hypertrophy[J].Chinese Pharmacological Bulletin,2004,20(2):121-124. |
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| Authors: | CHEN Chang-Xun JIN Ruo-Min SHEN Yun-Hui- |
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| Abstract: | Na +/H + exchanger 1 (NHE1) is a major contributor to ischemic and reperfusion injury. It is emerging that NHE 1 also contributes to myocardial hypertrophy and heart failure due to chronic maladaptive stimulation. It appears that NHE 1 may represent a common downstream mediator for various hypertrophic factor, such as angiotensinⅡ,beta (1) and alpha (1) adrenergic receptor activation. NHE 1 inhibition may be a effective new therapeutic approach for prevention and treatment of heart failure.- |
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| Keywords: | Na+/H+ exchange 1 myocardial hypertrophy angiotensinⅡ alpha (1) adrenergic receptor beta (1) adrenergic receptor[WT |
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