| 牙齿损伤后降钙素基因相关肽和胶质源性神经生长因子在三叉神经节中的表达变化 |
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| 引用本文： | 于静涛,林莉,刘纯义.牙齿损伤后降钙素基因相关肽和胶质源性神经生长因子在三叉神经节中的表达变化[J].口腔医学,2001,21(4):178-179. |
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| 作者姓名： | 于静涛 林莉 刘纯义 |
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| 作者单位： | 中国医科大学口腔医学院,沈阳,110002 |
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| 摘 要： | 目的:探讨降钙素基因相关肽(CGRP)和胶质源性神经生长因子(GDNF)在大鼠磨牙损伤后不同时段三叉神经节中表达变化。方法:制备大鼠磨牙机械损伤的模型,对其三叉神经节中CGRP和GDNF进行免疫组化染色。结果:在正常三叉神经节中CGRP呈阳性反应,GDNF染色呈阴性;损伤后即刻组CGRP染色阳性,GDNF少许表达;3天组GDNF染色强阳性;损伤5天后CGRP染色强阳性,GDNF表达开始减弱;损伤9天后两者表达恢复到正常水平。结论:CGRP和GDNF参与并促进牙齿损伤后的痛过敏及神经再生修复。
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| 关 键 词： | 降钙素基因相关肽 胶质源性神经生长因子 牙齿损伤 免疫组织化学 |
Changes of Calcitonin Gene-related Peptide and Glial Cell Line Derived Neurotrophic in Trgeminal Ganglia During Teeth Injury |
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| Yu Jingtao,Lin Li,Liu Chunyi.School of Stomatology,China Medical Univercity,Shen Yang.Changes of Calcitonin Gene-related Peptide and Glial Cell Line Derived Neurotrophic in Trgeminal Ganglia During Teeth Injury[J].Stomatology,2001,21(4):178-179. |
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| Authors: | Yu Jingtao Lin Li Liu ChunyiSchool of Stomatology China Medical Univercity Shen Yang |
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| Abstract: | Aim:To discuss expression and functions of calcitonin gene-related peptide and glial cell line derived neurotrophic in trgeminal ganglia during different stages of injured teeth.Methods:Model of rat molar teeth injury was established and immunohistochemical staining of CGRP and GDNF in trgeminal ganglia was carried on.Results:In the normal groups,CGRPexpresstion was obvious,GDNF expression was not observed;in 0 hour groups,the GDNF expression was very low;in 3d groups,GDNF expression increased greatly;in 5d groups, CGRP expression was the most,but GDNF was decreased;in 9d groups both of them were as same as the normal groups.Conclusion:CGRP and GDNF may take part in the reaction and nerve restoration after teeth injury |
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| Keywords: | CGRP GDNF Teeth injury Immunohistochemistry |
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