Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment |
| |
| Authors: | AT Soliman A Rajab I AlSalmi A Darwish M Asfour |
| |
| Affiliation: | Department of Paediatrics, Royal Hospital, Muscat, Oman. |
| |
| Abstract: | Short stature is a characteristic feature of pycnodysostosis. We report defective growth hormone secretion in response to provocation and low insulin-like growth factor-I (IGF-I) concentration in five out of six patients with pycnodysostosis. Physiological replacement with growth hormone increased IGF-I concentration and improved linear growth in these children. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
