Voltage-clamp analysis of a transient potassium current in rat neostriatal neurons |
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Authors: | D James Surmeier Jose Bargas ST Kitai |
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Institution: | Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163. |
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Abstract: | Whole cell voltage-clamp recordings were made from cultured rat neostriatal neurons. Depolarizing voltage commands evoked transient and sustained outward K-currents. The transient K-current was activated by depolarizing commands beyond -50 mV; peak current was dependent upon holding potential. Bath application of 4-aminopyridine, but not inorganic calcium channel blockers (Cd, Co, Mn), attenuated the transient current. Reversal was near the K-equilibrium potential. These properties suggest that this transient K-current is similar to the A-current described in a number of other neurons. |
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Keywords: | A-current Neostriatum Voltage-clamp Cell culture |
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