| 喜树碱前体多相脂体的药理学研究 |
| |
| 引用本文： | 胡成久,周晓燕,顾学裘,孙鉴堂,张宝凤.喜树碱前体多相脂体的药理学研究[J].沈阳药科大学学报,1990(2). |
| |
| 作者姓名： | 胡成久 周晓燕 顾学裘 孙鉴堂 张宝凤 |
| |
| 作者单位： | 中国医学科学院药物研究所
(胡成久)，沈阳药学院药剂研究所
(周晓燕，顾学裘)，沈阳药学院肿瘤研究室
(孙鉴堂)，沈阳药学院肿瘤研究室(张宝凤) |
| |
| 摘 要： | 本文报道了对喜树碱前体(A-CPT)及喜树碱前体多相脂质体(A-CPT-pl)的药理学研究结果。结果表明,A-CPT腹腔注射给药(ip)及经口腔给药(PO),寇氏法求得小鼠的LD50分别为159.3mg/kg及33.7mg/kg,较喜树碱钠盐(CTP-Na)的毒性降低,按最大允许给药容量(0.5ml/10g)ip或PO A-CPT-pl 50mg/kg,在观察期间未见死亡。抑瘤试验结果表明,A-CPT-pl对S180及HepS的抑制率可达74%及82%,可使荷EAC小鼠的生命延长126%;A-CPT对S180及HepS的抑制率可达52%及53%,可使荷EAc小鼠的生命延长54%。肿瘤相伴免疫试验结果表明,每日ip,A-CPT-pl 0.5mg/kg,连续9天,对小鼠肿瘤相伴免疫没有明显影响。
|
| 关 键 词： | 喜树碱前体 脂质体 抑瘤试验 肿瘤相伴免疫 |
STUDIES ON THE PHARMACOLOGY OF POLY-PHASE LIPOSOME OF PRO-CAMPTOTHECIN |
| |
| Hu Chengjiu,Zhou Xiaoyan,Gu Xueqiu,Sun Jiantang,Zhang Baofeng,Shenyang College of Pharmacy.STUDIES ON THE PHARMACOLOGY OF POLY-PHASE LIPOSOME OF PRO-CAMPTOTHECIN[J].Journal of Shenyang Pharmaceutical University,1990(2). |
| |
| Authors: | Hu Chengjiu Zhou Xiaoyan Gu Xueqiu Sun Jiantang Zhang Baofeng Shenyang College of Pharmacy |
| |
| Abstract: | Reported in the present article are the results of our studies on the pharmacology
of pro-camptothecin (A-CPT)and its poly-phase liposome (A-CPT-PL). The ip
and po LD50 of A-CPT were 159.3rng/kg and 33.7mg/kg in mice, respectively, No
death was recorded in the period of observation after the administration of A-CPT-PL
50mg/kg by the same route. The inhibitory rates of A-CPT-PL against S180 and
HepS were 74% and 82%, respectively. The life span of mice bearing EAC was
prolonged to 126% by ip administration of A-CPT-PL 0.5mg/kg for 6 days. A-CPT-
PL had no effect on tumor concomity immunity after ip administration of A-CPT-PL
0.5mg/kg daily for 9 days. |
| |
| Keywords: | Pro-camptothecin Liposome Antitumor Tumor concomitant immurtity |
| 本文献已被 CNKI 等数据库收录！ |
|
