| 共患糖尿病的抑郁症患者皮质醇分泌节律的研究 |
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| 引用本文： | 仲爱芳,王晓辉,何益民,宋梓祥,陈琪,徐乐平. 共患糖尿病的抑郁症患者皮质醇分泌节律的研究[J]. 东南国防医药, 2011, 13(2): 140-142 |
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| 作者姓名： | 仲爱芳 王晓辉 何益民 宋梓祥 陈琪 徐乐平 |
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| 作者单位： | 解放军102医院检验科,江苏常州,213003 |
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| 摘 要： | 目的探讨同时伴有糖尿病的抑郁症患者皮质醇分泌节律的特点,及其在抑郁症患者所发生的糖尿病病理机制中的意义。方法确诊糖尿病的抑郁症30例(观察组)测定8∶00、16∶00、24∶00血浆皮质醇浓度,同时测定空腹血糖、糖负荷后2 h血糖,并与正常糖代谢的抑郁症30例(对照组)进行对照。结果①观察组8∶00、16∶00、24∶00血浆皮质醇浓度分别为(607±269)nmol/L、(416±178)nmol/L、(376±264)nmol/L,显著高于对照组(485±178)nmol/L、(290±154)nmol/L、(173±117)nmol/L,差异有统计学意义(P均<0.05)。②观察组皮质醇分泌节律消失者为73.3%,显著高于对照组的46.7%(P<0.05)。③观察组8∶00、24∶00的血浆皮质醇浓度与空腹血糖值正相关(r值分别为0.338、0.418,P<0.05)。结论下丘脑-垂体-肾上腺轴功能紊乱可能是抑郁患者产生糖尿病的重要机制之一。
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| 关 键 词： | 糖尿病 抑郁症 皮质醇 分泌节律 |
The diurnal rhythm of cortisol secretion in patients with comorbidity of depression and diabetes:a clinical control study |
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| ZHONG Ai-fang,WANG Xiao-hui,HE Yi-min,SONG Zi-xiang,CHEN Qi,XU Le-ping. The diurnal rhythm of cortisol secretion in patients with comorbidity of depression and diabetes:a clinical control study[J]. Journal of Southeast China National Defence Medical Science, 2011, 13(2): 140-142 |
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| Authors: | ZHONG Ai-fang WANG Xiao-hui HE Yi-min SONG Zi-xiang CHEN Qi XU Le-ping |
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| Affiliation: | ZHONG Ai-fang,WANG Xiao-hui,HE Yi-min,SONG Zi-xiang,CHEN Qi,XU Le-ping.Department of Clinical Laboratory,102 Hospital of PLA,Changzhou,Jiangsu 213003,China |
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| Abstract: | Objective To study the characteristics of diurnal rhythm of cortisol secretion in depression patients with diabetes.Methods Two groups including depressed patients with newly diagnosed diabetes(case group,n=30),depressed patients with normal glucose metabolism(control group,n=30),undertook the assessment of rhythm in cortisol secretion at 3 time point(8:00,16:00,24:00) and fasting plasma glucose,2h plasma glucose after 75g glucose loading measurement before administration.Results It was showed that the plas... |
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| Keywords: | diabetes depression cortisol rhythm of cortisol secretion |
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