| 半乳糖凝集素10与慢性鼻窦炎伴鼻息肉 |
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| 引用本文： | 李春花,刘肖,刘红兵. 半乳糖凝集素10与慢性鼻窦炎伴鼻息肉[J]. 山东大学耳鼻喉眼学报, 2021, 35(3): 106-111. DOI: 10.6040/j.issn.1673-3770.0.2020.163 |
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| 作者姓名： | 李春花 刘肖 刘红兵 |
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| 作者单位： | 南昌大学第二附属医院 耳鼻咽喉头颈外科,江西 南昌330006 |
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| 摘 要： | 半乳糖凝集素10(Galectin-10)被发现已有很长的历史,但是探索其病理作用的研究很少。近几年,半乳糖凝集素10受到越来越多的关注,特别是其在气道嗜酸性粒细胞疾病中研究越来越多。综述了Galectin-10历史回顾及其在慢性鼻窦炎中的相关研究,Galectin-10/CLC蛋白不仅仅可作为以2型免疫反应为特征的CRSwNP的生物标志物,而且可能在其发病机制中发挥一定作用,并且很有希望作为以2型免疫反应为特征的CRSwNP的药物靶点。
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| 关 键 词： | Galectin-10 CLC 嗜酸性粒细胞 CRSwNP EETosis |
Galectin-10 and chronic rhinosinusitis with nasal polyps |
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| LI Chunhua,LIU Xiao,LIU Hongbing. Galectin-10 and chronic rhinosinusitis with nasal polyps[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 106-111. DOI: 10.6040/j.issn.1673-3770.0.2020.163 |
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| Authors: | LI Chunhua LIU Xiao LIU Hongbing |
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| Affiliation: | Department of Otolaryngology & Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China |
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| Abstract: | Galectin-10(CLC, Charcot-Leyden crystal)was discovered a long ago, but until recently, few studies have explored its role in pathophysiology. In recent years, galectin-10 has received considerable attention, especially for its role in airway eosinophil diseases. Here, we provide a brief historical review of galectin-10 and related research focused on chronic rhinosinusitis. Galectin-10 is a biomarker for chronic rhinosinusitis with nasal polyps characterized by a type 2 inflammatory response and may play an important role in its pathogenesis. Thus, it is a promising potential drug target for this type of CRSwNP. |
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| Keywords: | Galectin-10 CLC Eosinophils CRSwNP EETosis |
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