E-cadherin和ZEB2在鼻腔鼻窦内翻性乳头状瘤中的表达及其临床意义

目的 探讨E-cadherin mRNA和ZEB2 mRNA在鼻腔鼻窦内翻性乳头状瘤(SNIP)中的表达及其临床意义.方法 采用荧光定量PCR法检测E-cadherin mRNA和ZEB2 mRNA在51例SNIP和20例增生鼻甲组织中的表达,探讨E-cadherin mRNA和ZEB2 mRNA表达与SNIP患者临床...

Expressions of E-cadherin and ZEB2 in sinonasal inverted papilloma and their clinical significance

Objective To investigate the expressions of E-cadherin and ZEB2 mRNAs in sinonasal inverted papilloma(SNIP)and assess their clinical significance.Methods Quantitative fluorescence polymerase chain reaction was performed to detect the expressions of E-cadherin and ZEB2 mRNAs in 51 cases of SNIP and 20 cases of hyperplastic turbinate tissues and investigate the relationship and correlation between E-cadherin and ZEB2 mRNA expressions and clinicopathological parameters of SNIP patients.Results The expression of E-cadherin mRNA was lower in SNIP than in hyperplastic turbinate tissue(P=0.007)and that of ZEB2 mRNA was higher in SNIP than in hyperplastic turbinate tissue(P=0.034),both with statistically significant differences.The low expression of E-cadherin mRNA and high expression of ZEB2 mRNA were not related to the age,sex,clinical stage,or recurrence of SNIP,but were related to the pathological differentiation of SNIP.Further,the difference between the atypical hyperplasia and malignant transformation groups was statistically significant.The expressions of E-cadherin and ZEB2 mRNAs correlated negatively(r=-0.317,P=0.023).Conclusion In SNIP,the E-cadherin mRNA expression was downregulated,whereas ZEB2 mRNA expression was upregulated,showing a negative correlation.Both abnormal expressions were related to the pathologic differentiation of SNIP.The mechanism may be downregulation of the E-cadherin expression by ZEB2,promoting the occurrence and malignant transformation of SNIP.