外耳道腺样囊性癌的远处转移及预后分析

目的 探讨外耳道腺样囊性癌远处转移的相关危险因素及其对预后的影响.方法 回顾性分析22例江苏省人民医院2007年6月至2019年3月行原发灶根治手术且病理确诊为外耳道腺样囊性癌患者的临床和随访信息,单因素及多因素回归分析远处转移的危险因素及其对预后的影响.结果 患者远处转移率为40.9％,其中肺转移发生率最高,达66....

Analysis of distant metastasis and prognosis of adenoid cystic carcinoma of the external auditory canal

Objective This study aimed to investigate the risk factors of distant metastasis of adenoid cystic carcinoma of the external auditory canal and its influence on prognosis.Methods We performed a retrospective analysis of the clinical data and follow-up information of 22 patients who underwent radical surgeries and were diagnosed with adenoid cystic carcinoma of the external auditory canal by pathology.They were admitted to the First Affiliated Hospital of Nanjing Medical University from June 2007 to March 2019.The risk factors of distant metastasis and their influence on prognosis were analyzed by univariate and multivariate analyses.Results The rate of distant metastasis in this group was 40.9%,and the incidence of lung metastasis was the highest(66.7%).Univariate analysis showed that positive surgical margin and lymphatic metastasis during the operation were related to distant metastasis of adenoid cystic carcinoma of external auditory canal(P<0.05).Multivariate regression analysis showed that positive surgical margin and lymphatic metastasis were significantly associated with distant metastasis(P<0.05).The 5-year and 10-year overall survival rates of patients with adenoid cystic carcinoma of the external auditory canal who developed distant metastasis were 44.4%and 16.7%,respectively,while those without distant metastasis had 100%5-year and 10-year survival rates.The difference was statistically significant(P<0.05).Conclusion Adenoid cystic carcinoma of the external auditory canal has a higher rate of distant metastasis,with predominant lung metastasis.Positive surgical margin and lymphatic metastasis were were independent risk factors for distant metastasis,which is an important indicator affecting the prognosis of patients with the tumor.