| 外泌体在甲状腺癌的研究进展 |
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| 引用本文： | 张轶轶,薛刚,金春亭.外泌体在甲状腺癌的研究进展[J].山东大学耳鼻喉眼学报,2021,35(2):131-135. |
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| 作者姓名： | 张轶轶 薛刚 金春亭 |
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| 作者单位： | 河北北方学院 基础医学院,河北 张家口075000 |
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| 基金项目： | 河北省财政厅专科能力建设和专科带头人培养项目(361009);张家口市科技计划项目(1911019D) |
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| 摘 要： | 外泌体是一种直径50~140 nm的细胞外囊泡,包含DNA、RNA、蛋白质等多种内容物,几乎来源于所有类型的细胞。外泌体存在于血液、乳汁、尿液,通过传递生物活性分子在细胞间通讯中起着关键作用。论文综述外泌体的概况、功能及应用,总结外泌体miRNAs和circRNAs对甲状腺癌的影响及作为一种新型生物标志物的潜能。
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| 关 键 词： | 甲状腺癌 外泌体 细胞外囊泡 微小RNA 生物标志物 |
Research progress of exosomes in thyroid cancers |
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| ZHANG Yiyi,XUE Gang,JIN Chunting.Research progress of exosomes in thyroid cancers[J].Journal of Otolaryngology and Ophthalmology of Shandong University,2021,35(2):131-135. |
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| Authors: | ZHANG Yiyi XUE Gang JIN Chunting |
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| Institution: | 1. Basic Medical College, Hebei North University, Zhangjiakou 075000, Hebei, China;2. Department of Otorhinolaryngology & Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075061, Hebei, China;3. Department of Pathology, Hebei North University, Zhangjiakou 075000, Hebei, China |
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| Abstract: | The exosome are extracellular vesicle with a diameter of 50-140 nm, generated by almost all types of cell and carrying nucleic acids, proteins, lipids, and metabolites. They are found in all biological fluids such as blood,milk,urine etc.and play a key role in intercellular communication by delivering active biomolecules. This paper rviews the general situation, functions and applications of exosomes, summarize the effects of exosomal miRNAs and circRNAs in thyroid carcinoma and the potential as a new type of biomarkers. |
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| Keywords: | Thyroid cancers Exosome Extracellular vesicles MicroRNAs(miRNA) Biomarkers |
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